BACKGROUND Hepatocellular carcinoma(HCC) may be caused by hepatitis B virus(HBV) infection. Post-infection recovery-associated changes of HBV indicators include decreased hepatitis B surface antigen(HBsAg) level and increased anti-HBsAg antibody titer. Testing to detect HBV DNA is conducted rarely but...
Hepatitis B (Chapter 150) vaccine is the first vaccine that can prevent cancer (an estimated 800 persons per year in the United States die of hepatitis B–related liver cancer; many times more die in the developing world). It also can prevent acute and chronic complications of hepatitis B, ...
HBsAg level reflects the transcriptional activity of the cccDNA. It is an important marker that might not only indicate active hepatitis B infection, but may also predict clinical and treatment outcomes. Assays for HBsAg quantification are fully automated with a high output capacity. HBsAg titer is...
Hepatitis B virus-specific and global T-cell dysfunction in chronic hepatitis B. Gastroenterology. 2016;150(3):684-695.e5. Article CAS PubMed Google Scholar Michler T, Kosinska AD, Festag J, et al. Knockdown of virus antigen expression increases therapeutic vaccine efficacy in high-titer ...
active liver inflammation, a high ALT level, and high levels of HBV DNA. But most primary care clinicians are not going to be doing that treatment on their own. We go into so much detail about this on the podcast. Click here to listen to the full podcast,Hepatitis B with Dr Arthur ...
B infection in whichHBeAgis also positive, there are usually active viral replication and significant liverinjury. In time, HBeAg may be lost, replaced by its antibody, anti-HBe. This transformation is often associated with lower level infection (less viral replication) orHBVDNA, lower AST and...
Hepatitis B surface antigen (HBsAg) levels were quantified (qHBsAg) using the Elecsys HBsAg quant Assay (Roche Diagnostics GmbH, Mannheim, Germany). In samples with qHBsAg titer below the threshold of the assay (0.05 IU/mL), HBsAg clearance was verified with the qualitative Elecsys HBsAg test...
乙肝五项(HepatitisBfive) ThemeaningoffiveitemsofhepatitisB Two,halfacheckisusedtodeterminewhethertheinfection ofhepatitisBorroughestimateofthelevelofreplication oftheviruspreliminaryexamination,twohalfoftheseverity ofthediseaseassessment,referenceisnotlarge.Liver functionisanimportantexaminationtomeasurewhetherthe liver...
The administration of antiviral therapy in patients diagnosed with B virus infection is controversial because increasing antibody titer has been demonstrated in a patient following its discontinuation (Cohen et al., 2002). The determination of the most efficacious antiviral(s) for use is ongoing (...
(e.g., subjects withchronic renal failure, hemodialysis patients, HIV-positive subjects), boosters should be administered to maintain anti-HBs antibody titer equal to or higher than the accepted protective level of 10 IU/L. For these immunocompromised subjects, post-vaccination testing every 6–12...