5B). The anti-HBs titer exhibited a significant negative correlation with the proportion of CD24+CD38highBreg cells (r = -0.402, p = 0.042). Discussion With the optimization of hepatitis B antiviral-treatment strategies, the number of patients achieving HBsAg seroclearance has increased [11...
10 For dogs that recover from illness, a recent history of vaccination may complicate interpretation of acute and convalescent phase serology. In the absence of a vaccination history, a fourfold rise in titer over a 2- to 3-week period together with compatible clinical signs is supportive of ...
HBsAg titer having fallen below the level of detection in those with chronic infection.25 View article Special Issue: Predictive and diagnostic autoantibodies MayaRam, ...YehudaShoenfeld, inAutoimmunity Reviews, 2008 4Results Hepatitis B core antibody(HBcAb) was examined in 675 sera of different aut...
Interpretation of HBV serologic test results HBsAg HBsAb HBcAbIgM HBcAbIgG HBeAg HBeAb HBV DNA Acute + − + − + − + Resolved HBV − + − + − + − Inactive carrier state + − − +/− − + − Chronic HBV + − − +/− +/− − + Vaccine induced immun...
RNA interference is a novel treatment strategy for chronic hepatitis B. RNA interference agents have entered phase II/III clinical trials, demonstrating promising results in inducing hepatitis B surface antigen seroclearance. RNA interference agents will likely be the keystone of future hepatitis B treatm...
Hepatitis B virus and hepatitis C virus remains one of the leading causes of morbidity and mortality worldwide, particularly in countries with limited resources. The two hepatotropic viruses have common mode of transmission. Hepatitis B virus and hepatit
Differentiating between an acute and chronic hepatitis B infection was often difficult. Large clinical studies initiated by Reiner Thomssen (Göttingen, Germany) in the 1970s showed that the interpretation of the IgM anti-HBc results obtained by the author was not as straightforward as most clinica...
The interpretation is based on the qualitative test results for hepatitis A serology (anti-HAV, IgM anti-HAV, and HAV-RNA); the qualitative test results for hepatitis B serology (HBsAg, anti-HBs, anti-HBc, IgM anti-HBc, HBeAg, and anti-HBe) and the quantitative test result for anti-HBs...
1b, left, MOI10, and 1c, upper, MOI 10), cytotoxicity was observed at much higher MOIs. Therefore, AdVs must be used within the range lower than the cytotoxic level. Also, the differences in titration methods may influence the interpretation of the experimental results. The apparent titers...
Hepatitis B surface antigen (HBsAg) levels were quantified (qHBsAg) using the Elecsys HBsAg quant Assay (Roche Diagnostics GmbH, Mannheim, Germany). In samples with qHBsAg titer below the threshold of the assay (0.05 IU/mL), HBsAg clearance was verified with the qualitative Elecsys HBsAg test...