To a minor degree, transplacental transmission presumably is responsible for perinatal infections, depending on risk factors including maternal HBeAg positivity, HBsAg titer, and HBV DNA level.67 Despite the use of effective active and passive immunoprophylaxis, perinatal transmission might still occur.2...
(Table 37.2). The majority of patients with HBV worldwide have immune controlled and inactive disease withHBsAgpositivity but normalliver enzymesand low titer HBV DNA in serum. Activation of HBV can occur at any time and is manifest by the presence ofHBeAgin serum, elevatedserum aminotransferase...
Shibata M, Morizane T, Tanaka A, Onozuka Y, Uchida T, Gershwin ME and Mitamura K. A case of autoimmune hepatitis with a high titer of antimitochondrial antibody and normal gamma- globulinemia.J Gastroenterol Hepatol. 2001; 16: 830- 835....
Hepatitis B virus-specific and global T-cell dysfunction in chronic hepatitis B. Gastroenterology. 2016;150(3):684-695.e5. Article CAS PubMed Google Scholar Michler T, Kosinska AD, Festag J, et al. Knockdown of virus antigen expression increases therapeutic vaccine efficacy in high-titer ...
Tenofovir disoproxil fumarate (TDF) is one of the nucleotide analogs capable of inhibiting the reverse transcriptase (RT) activity of HIV and hepatitis B virus (HBV). There is no known HBV resistance to TDF. However, detectable variation in duration of HBV persistence in patients on TDF therapy...
Hepatitis B surface antigen (HBsAg) levels were quantified (qHBsAg) using the Elecsys HBsAg quant Assay (Roche Diagnostics GmbH, Mannheim, Germany). In samples with qHBsAg titer below the threshold of the assay (0.05 IU/mL), HBsAg clearance was verified with the qualitative Elecsys HBsAg test...
Recent development of hepatitis B virus (HBV) culture systems has made it possible to analyze the almost all steps of the viral life cycle. However, the reproducibility of interaction between HBV and host cells seemed inaccurate in those systems because of utilization of cancer cell lines with a...
[14]. The presence of hepatitis B core protein antibody (anti-HBc) is an evidence of nature HBV infection. High titer IgM class anti-HBc can be seen in acute hepatitis B. The presence of HBeAg in patients’ serum is an indicator of the immune tolerance phase with active HBV replication....
cerevisiae.Hepatitis B vaccine, the first licensed vaccine made by use ofrecombinant techniques, produces adequateantibody responsesin more than 90% of normal adults and more than 95% of normal infants, children, and adolescents when it is administered in a three-dose series. The dosage depends ...
The administration of antiviral therapy in patients diagnosed with B virus infection is controversial because increasing antibody titer has been demonstrated in a patient following its discontinuation (Cohen et al., 2002). The determination of the most efficacious antiviral(s) for use is ongoing (...