S/β°-thalassemia can differ from SS disease in that there may be less severe hemolysis and splenomegaly. S/β+-thalassemia (in which some normal β-globin chains are produced) is a milder disease and, in fact, is asymptomatic in many cases. Pathologic Features The peripheral blood sme...
We report the first case of hemoglobin (Hb) SC disease with development of severe anemia induced by cold agglutinin hemolysis after Mycoplasma infection. Complete blood count (CBC) showed falsely decreased RBC count and hematocrit and falsely elevated MCV and MCHC. Peripheral blood smear showed RBC...
(CBC) and peripheral smear. It is also important to note that drugs (hydroxyurea,sodium valproate, and erythropoietin) and stresserythropoiesismay also result in high Hb F.Hydroxyureais used in sickle cell disease patients to increase the amount of Hb F, the presence of which may help to ...
(SCD) includes all manifestation of abnormal hemoglobin S (HbS) which includes sickle cell trait (Hb AS), homozygous sickle cell disease (Hb SS), and a range of mixed heterozygous hemoglobinopathies such as hemoglobin SC disease, hemoglobin SD disease, hemoglobin SO Arab disease, and hemoglobin...
The clinical presentation of Hb SO Arab in this patient resembled that of Hb SD disease. Her hemoglobin varied from 9.9 to 10.5 gm/dl and reticulocyte count from 1.2 to 2.5%. The peripheral blood smear showed moderate anisopoikilocytosis, moderate polychromasia and occasional sickle forms. The...
Peripheral blood smearPeripheral Blood SmearAnemia: Overview and Types LDHOsteosarcoma BilirubinBilirubinA bile pigment that is a degradation product of heme.Heme Metabolism Haptoglobin Genetic testingGenetic TestingDetection of a mutation; genotype; karyotype; or specific alleles associated with genetic traits...
Critical evaluation of peripheral smear in cases of anemia with high mean corpuscular hemoglobin concentration in children: A series of four cases.Critical evaluation of peripheral smear in cases of anemia with high mean corpuscular hemoglobin concentration in children: A series of four cases.doi:10.41...
James Herrick first described sickle cell disease from observing the peripheral smear of a West Indian patient. The ocular manifestations of sickle cell disease were described by Cook in 1930 when he noticed retinal hemorrhages in a patient who died of subarachnoid hemorrhage. ...
2% of Thai have it) Thalassemia Lab Changes High RBC Low H&H and indices High RDW May need to rule out IDA Hb ELP not useful except in Hb H BCB prep for Hb H Hb H Prep with Brilliant cresyl blue a thalassemia Hydrops fetalis Peripheral blood smear: Hb H disease Thalassemia...
The peripheral blood smear showed both target and sickle cells. Hemoglobin electrophoresis confirmed the diagnosis of HB SC disease (HB S 55% and HB C 45%). Pancultures were negative. CT scan of brain demonstrated multiple infarcts. Exchange transfusion was done and patient improved gradually. ...