Hemoglobin C disease is one-fourth as frequent as sickle cell disease among African Americans. Laboratory testing reveals mild anemia and mild reticulocytosis. The predominant RBC abnormality on the peripheral smear is an abundance of target cells, and crystal-containing cells also may be seen (Fig...
(CBC) and peripheral smear findings. It is also important to note that drugs (hydroxyurea,sodium valproate, erythropoietin) and stresserythropoiesiscan also result in high HbF.Hydroxyureais used in sickle cell disease patients to increase the amount of HbF, the presence of which can help reduce ...
Crystal formation (classically, hexagonal-shaped crystals on peripheral blood smear) may result, which can lead to increased blood viscosity and cellular rigidity and shortened erythrocyte survival. Unlike sickle cell disease (SCD), Hb C does not cause linear intracellular polymerization of red cells ...
Rod-shaped hemoglobin crystalsCluesHemoglobin C diseaseThe typical rod-shaped HbC crystals in the peripheral blood smear often provide the diagnostic clue to the HbC disease. This case highlights that a careful review of blood film morphology may be helpful to detect HbC disease, although this case...
Peripheral Smear Platelet Disorders Platelet Count Platelet Morphology on Peripheral Smear Mean Platelet Volume Platelet Function Closure Time Acute Phase Reactant Complement Pathway C-Reactive Protein C-Reactive Protein as Cardiac Risk Factor Serum Cryoglobulin Erythrocyte Sedimentation Rate ...
~xamGation of the peripheral blood smear disclosed slight hypochromia and anisocytosis. The patient received a therapeutic trial of multivi- tamins with iron, but the anemia persisted. Over the next 5 years, the patient received several courses of oral elemental iron therapy, without improvement...
Peripheral blood studies revealed hematocrit 21 %, hemoglobin 7.0 g/100 ml, 13 nucleated RBCs/100 WBCs, and an uncorrected reticulocyte count of 5.3% (Table 1). On peripheral smear the red cells exhibited marked anisocytosis and poikilocytosis with many target cells, spherocytes, and ...
-CBC: low hct, low hgb, sickle cells seen on peripheral smear -Can have low haptoglobin,increased reticulocytes,and increased bilirubin -Hemoglobin electrophoresis shows presence ofHGB S -Hgb solubility testing Vaso-Occlusive Crisis -AKA pain crisis ...
A peripheral blood smear revealed microcytic hypochromic red cells with some target cells. Hemoglobin electrophoresis showed a very high percentage of hemoglobin E, a very low percentage of hemoglobin A2, and normal proportions of hemoglobin A and hemoglobin F. A diagnosis ...
unconjugated bili increased (b/c hemolysis) UA may show hemoglobinuria peripheral smear: - schistocytes (fragmented RBCs) - spherocytes (maybe - small round RBCs) - sickle cells - bite cells (d/t heinz body removal, seen in G6pd)