Peripheral blood smear showing a mixture of RBCs, some with round normal morphology and some with sickling (elongation and bending) Image:“Sickle Cell Anemia” by Ed Uthman. License: CC BY 2.0 Related videos 3:58 Sickle Cell Anemia: Clinical Pathology and Diagnosis 1:25 Sickle Cell Anemia:...
Sickle-cell diseaseMicroscopy imageMachine learningInterpretabilityMorphology analysisIn this work we propose an approach to select the classification method and features, based on the state-of-the-art, with best performance for diagnostic support through peripheral blood smear images of red blood cells....
Additionally, these methods are able to differentiate homozygous SCD (HbSS, sickle cell anemia) from double heterozygous inheritance of the sickle gene and other abnormal hemoglobins (eg, HbSC, HbSD, Hb S/β-thalassemia, and HbSO-Arab). The peripheral smear shows sickle cells (Fig. 3). ...
In fact, each year hundreds of thousands of blood smear slides are prepared in sub-Saharan Africa to make diagnosis of blood cell infections and disorders15. Peripheral blood smears, exhibiting variations in e.g., the size, color, and shape of the red blood cells can provide diagnostic ...
Peripheral blood smear Pulmonary function tests (transcutaneous O2 saturation) Kidney function (creatinine, BUN, urinalysis) Hepatobiliary function tests, (ALT, fractionated bilirubin) CSF examination: Consider lumbar puncture in febrile children who appear toxic and in those with neurologic findings ...
What is sickle cell anemia and what would a peripheral blood smear look like from a sickle cell patient? Hemoglobin: Hemoglobin is a conjugated protein made up of iron, protoporphyrin IX type III and globin. The globin portion is made of four protein subunits,...
diagnostics for sickle cell disease peripheral blood smear - reveals sickled cells and increased abnormal reticulocytes hemoglobin electrophoresis - determines the amount of hemoglobin S- skeletal x-ray show bone/joint deformities and flattening MRI diagnosis strokedoppler diagnosis DVTchest x-ray - diagno...
How do you make the diagnosis of sickle cell anemia? Hemoglobin electrophoresis shows the presence of hemoglobin S. The peripheral smear shows characteristic sickle cells, and, often, Howell-Jolly bodies Hematological indices in individuals with HbSS? Individuals with HbSS have low Hb and low RBC ...
The peripheral blood smear in patients with sickle cell trait: a morphologic observation 10.1309/GTAK-UB4N-HPN3-GTD1 Lab Medicine, 31 (8) (2000), pp. 445-447 Google Scholar 19. S.L. Brown, J.R. Ewing, T.N. Nagaraja Sickle red blood cells accumulate in tumor 1:STN:280:DC%2BD3s...
Bernaudin et al., Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease. Blood. Oct. 1, 2007;110(7):2749-56. Epub Jul. 2, 2007. Berthold et al., cis-acting elements in human immunodeficiency virus type 1 RNAs direct viral transcripts to distinc...