刺猬信号通路(英语:Hedgehog signaling pathway)是重要的信号传导通路。共有五种刺猬因子:音猬因子(Sonic hedgehog,SHH)、沙漠刺猬因子(desert hedgehog,DHH)、印度刺猬因子(Indian hedgehog,IHH)、Echidna Hedgehog,EHH和Tiggywinkle Hedgehog,TwHH)。仅在鱼类中发现有EHH和TwHH,哺乳类和其他动物中没有这两种刺猬因子。
硬皮动物(Hedgehog)信号通路是一种高度保守的细胞信号传导途径,起初在果蝇中发现。该通路在胚胎发育、器官形成和细胞增殖调控等生理过程中起着重要作用。它由配体(Shh)、受体(Ptch1/2)、转导蛋白(Smo)以及多个调节因子组成。hedgehog家族有三个成员,分别是sonic hedgehog (Shh)、desert hedgehog (Dhh)和Indian hedgehog...
Hedgehog Signaling: A Potential Mechanism of Therapeutic 选择语言:从中文简体中文翻译英语日语韩语俄语德语法语阿拉伯文西班牙语葡萄牙语意大利语荷兰语瑞典语希腊语捷克语丹麦语匈牙利语希伯来语波斯语挪威语乌尔都语罗马尼亚语土耳其语波兰语到中文简体中文翻译英语日语韩语俄语德语法语阿拉伯文西班牙语葡萄牙语意大利语荷兰语...
Hedgehog signaling: a biophysical or biomechanical modulator in embryonic development? Ann N Y Acad Sci . 2007;1101:412–438.Nagase, T., Nagase, M., Machida, M., Yamagishi, M. 2007. Hedgehog signaling: a biophysical or biomechanical modulator in embryonic development? Ann. N. Y. Acad. ...
Hedgehog and Notch signaling in enteric nervous system development 相关诺奖: 1971,发现并阐述cAMP的功能并提出第二信使学说; 1994,发现G蛋白及其在细胞信号转导中的调控作用; 1992,发现蛋白质磷酸化与去磷酸化的调控机制; 1998,NO作为气体信号引起血管平滑肌舒张; ...
TheHedgehogproteins are secreted molecules that act through a receptor complex involving two additional proteinsPatchedandSmoothened. The current model for hedgehog signaling suggests that, in the absence of Hedgehog, Patched inhibits Smoothened and thus prevents signaling. When Hedgehog binds to Patched, ...
Hedgehog signaling Introduction of Hedgehog signaling pathway The initiation of Hedgehog signaling is based on the processing of Hedgehog ligands in secretory cells, where a dual lipid-modified amino-terminal (N-terminal) polypeptide of the autocatalytically cleaved precursor protein is formed.8Signal rec...
development Hedgehog mechanism signaling Introduction The Hedgehog (Hh) pathway is one of several major signaling pathways that control key steps of embryonic development.1, 2, 3 Hh signaling also participates in tissue homeostasis and regeneration4 while perturbation of Hh signaling is associated with ...
hedgehog co-receptor, Smoothened, or that lack activity of Shh, Ihh, or both, exhibit multiple defects in cardiac development, including reduced heart size (Zhang et al., 2001). Tissue specific ablation of Hh signaling components in different cardiac progenitors indicates that Hh signaling is ...
The Hedgehog(Hh) signaling pathway functions as an organizer in embryonic development,and this pathway has been elucidated in detail by genetic studies in Drosophila.But our recent results show that in the mammalian Hh pathway Su(Fu),instead of Cos2,plays a critical role.Thus,Drosophila and mamm...