Gorojankina T. Hedgehog signaling pathway: a novel model and molecular mechanisms of signal trans- duction. Cell Mol Life Sci 2016;73:1317-1332.Gorojankina, T. (2016) Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction. Cellular and Molecular Life Sciences ...
Hedgehog signaling pathway modulates osteogenic differentiation in novel oxysterol-conditioned rabbit bone marrow stromal cellsPurpose: To determine the osteogenic capacity of a novel growth factor on rabbit b one marrow stromal cells. Background: Current reconstructive techniques for complex craniofacial ...
The Hedgehog signaling pathway refers to a critical pathway involved in embryogenesis and the regulation of cell renewal and survival. It plays a significant role in regulating the cancer stem cell niche in several human cancers, including prostate cancer. Activation of this pathway leads to the exp...
5. Pan JY, Zhou SH. The hedgehog signaling pathway, a new therapeutic target for treatment of ischemic heart disease. Pharmazie.2012 Jun;67(6):475-81. [PMID: 22822532].联科生物代理截止时间:2017年6月30日
The hedgehog pathway inhibitor cyclopamine increases levels of p27, and decreases both expression of IGF-II and activation of Akt in PC-3 prostate cancer cells. Cancer Lett. 255, 300–306 (2007). Article CAS PubMed Google Scholar Lipinski, R. J. et al. Sonic hedgehog signaling regulates ...
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation[J]. Curr Mol Med, 2009,9(7):873-886. DOI: 10.2174/156652409789105570 . 返回引文位置Google Scholar 百度学术 万方数据 [8] Gorojankina T . Hedgehog signaling pathway: a novel model and molecular ...
et al. Oxysterols are novel activators of the Hedgehog signaling pathway in pluripotent mesenchymal cells. J. Biol. Chem. 282, 8959–8968 (2007). Article CAS PubMed Google Scholar Corcoran, R. B. & Scott, M. P. Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of ...
产品活性:Cyclopamine 是 Hedgehog 通路的拮抗剂,在细胞实验中的 IC50 为 46 nM。Cyclopamine 还是一种选择性的 Smo 抑制剂。 生物活性:Cyclopamine 是一种Hedgehog(Hh) 通路拮抗剂,在 Hh 细胞试验中的IC50为 46 nM。 Cyclopamine 也是一种选择性Smo抑制剂。 IC50 和目标:IC50:46 nM(Hedgehog,在 Hh 细胞试验中...
Do tumours arise from stem cells, or are they derived from more differentiated cells that, for some reason, begin to recapitulate developmental programmes? Inappropriate activation of the Sonic hedgehog–Gli signalling pathway occurs in several types of
Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell 2006; 10(2): 187–197. 46 Cooper AF, Yu KP, Brueckner M et al. Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. ...