cells in liver cancer revealed by single-cell sequencing[J]. Cell, 2017, 169(7): 1342-1356. e16. DOI: 10.1016/j. cell.2017.05.035. [23] Zhang Q, He Y, Luo N, et al. Landscape and dynamics of single immune...
这也说明单细胞测序只要有好的idea,即使是很简单的分析,也能把文章发出去哦!参考文献:Chen VL, Huang Q, Harouaka R, et al. A Dual-Filtration System for Single-Cell Sequencing of Circulating Tumor Cells and Clusters in HCC.Hepatol Commun. 2022;6(6):1482-1491. doi:10.1002/hep4.1900...
Single-cell RNA sequencingHEPATOCELLULAR-CARCINOMAPROMOTES PROLIFERATIONTUMOR MICROENVIRONMENTPLEIOTROPHINBackgroundCancer-associated fibroblasts (CAFs) are essential stromal components in the tumor microenvironment of hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) infection induces pathological changes such ...
Lu J, Chen Y, Zhang X, Guo J, Xu K, Li L. A novel prognostic model based on single-cell RNA sequencing data for hepatocellular carcinoma. Cancer Cell Int. 2022 Jan 25;22(1):38. doi: 10.1186/s12935-022-02469-2. PMID: 35078458; PMCID: PMC8787928....
文献二:Single-Cell Multiomics Sequencing RevealsPrevalent Genomic Alterations in Tumor StromaCells of Human Colorectal Cancer(IF 38) 在本研究中,作者对21名微卫星稳定结直肠癌患者和6名未被诊断为癌症的老年正常人的样本进行了单细胞多组学测序。根据不同细胞类型特异性表达基因,所有细胞能够被分为8个主要细胞...
发表题目:Integrating single‑cell and bulk RNA sequencing reveals CK19+cancer stem cells and their specifc SPP1+tumor‑associated macrophage niche in HBV‑related hepatocellularcarcinoma 发表期刊:Hepatology International 二、摘要 摘要: 目的:细胞角蛋白19阳性癌症干细胞(CK19+ CSCs)及其肿瘤相关巨噬细...
目前MSI-H主要有4种检测方法,包括IHC检测MMR蛋白的表达、多重荧光PCR毛细血管电泳法、二代测序(next generation sequencing,NGS)及外周血循环肿瘤 DNA(circulating tumor DNA,ctDNA),需要指出的是,在实际临床实践过程中应根据患者个人的实际...
就免疫微环境改造而言,TKIs、ICIs、TACE、HAIC、SBRT(立体定向放射治疗)等手段可能在肿瘤免疫循环的不同阶段充当了免疫原性死亡(immunogenic cell death,ICD)诱导剂的角色[39]。从这个概念出发,未来的肝癌全病程体系应全面进行MDT管理,欧...
New technologies such as single-cell sequencing, spatial-omics sequencing and deep learning-based artificial intelligence have led to breakthroughs in basic research of liver cancer. A more comprehensive understanding of the biological characteristics of HCC will push the breakthroughs in industry-...
[30]. The differentiation of these macrophage subtypes occurs under distinct conditions. While recent advancements in single-cell RNA sequencing techniques have revealed the existence of additional macrophage phenotypes, the M1 and M2 categories remain the predominant phenotypes used to distinguish ...