For total IgG, the half-life found was 25.8 days; for IgG1 it was 29.7 days; for IgG2 it was 26.9 days; and for IgG3 it was 15.7 days. The results are similar to those reported for endogeneous IgG. Half-lives for antibodies to S. minnesota (Re 595 mutant), cytomegalovirus, and ...
half‐life improvementIgG4 antibodiesneurodegenerative conditionspharmaceutical agentsThis chapter considers technologies for adjusting the half‐life of antibodies to perform optimally according to their therapeutic goals. FDA‐approved monoclonal antibodies (mAbs) comprise a wide range of therapies, targeting ...
the half-life or fractional catabolic rate of IgG is not fixed but varies inversely with the concentration of IgG. Thus, the half-life of IgG in patients with agammaglobulinemia may be greater than 35 days, but it may be as short as 10 days in patients with hypergammaglobulinemia. IgG...
This is in- teresting since the half-life of IgG3 is normally consid- ered to be considerably shorter than the other subclasses [56]. The short half-life noted here for IgG2 and IgG4 might help in explaining why IgG1 and IgG3 are often considered the most important ones...
Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dosing, frequenc
The half-life of maternal IgG in lambs has been reported to vary from 14 to 25 days (Pearson and Brandon, 1976; Campbell et al., 1977; Whitelaw and Jordt, 1985; Watson, 1992). Thus by 12 weeks of age, the S/P and avidity values would overwhelmingly reflect the lamb's own ...
Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune ... The MHC class I-like Fc receptor FcRn plays an essential role in extending the half-life (t(1/2)) of IgG antibodies and IgG-Fc-...
The biologic half-lives of tissue-localized antibodies were calculated from data collected between the 3rd and the 27th day after intravenous administration of radioglobulins. The biologic half-life of brain-localized antibody was 7.4 days and that of spleen-localized antibody, 5.8 days. The ...
The kinetics of clearance of 125I from the popliteal lymph nodes and feet of human serum albumin (HSA)-immunized mice was studied following the injection of [125I]-HSA into the hind footpads. Antigen was cleared from both locations rapidly for the first few days. The antigen half-life (T...
The biological half-life of the drug is the time in which the duration of action falls to one half of its original duration. This t½ refers to the time of the drug's response rather than the plasma concentration. Several drugs have durations of action that are longer than the plasma ...