half‐life improvementIgG4 antibodiesneurodegenerative conditionspharmaceutical agentsThis chapter considers technologies for adjusting the half‐life of antibodies to perform optimally according to their therapeutic goals. FDA‐approved monoclonal antibodies (mAbs) comprise a wide range of therapies, targeting ...
orhalf′ life`, n.,pl.-lives(-ˌlaɪvz) 1.the time required for one half the atoms of a given amount of a radioactive substance to decay. 2.the time required for the activity of a substance taken into the body to lose one half its initial effectiveness. ...
摘要: The half-life of intravenously injected murine anti-DNP IgE antibody was determined in recipient mice by sequential bleeding and was found to be 12 h. Intradermally injected IgE antibody persisted much longer, the half-life was 6 days.关键词:...
How- ever, it seems that some antibodies, such as those against MSP1, can have a half-life that spans over many years [16]. It is known that antibodies are an important compo- nent of acquired immunity, and it has been shown that passive transfer of antibodies from immu...
Estimates for the biological half-lives of the antibodies ranged from 18 to 24 days in neonatal lambs and 12 to 17 days in adult wethers. The evidence suggested that both normal and immunosuppressed wethers which were passively immunized with serum antibody catabolized this antibody at a faster...
It is worth noting that the period between D21 and D45 is 24 days, a period of normal decay in the acquired SE-specific antibodies of the ewes, due to their well documented half-life of 12–17 days [30]. This decline was noted at D45 in T3 ewes (OD = 0.572) and T4 ewes (OD...
Tunable pharmacokinetics: modifying the in vivo half-life of antibodies by directed mutagenesis of the Fc fragment Immunoglobulins (Igs) are large proteins of 150 kDa with prolonged residence time in blood. Their half-life is controlled by their ability to interact with... T Olafsen,VE Kenanova...
Antibody fragments: Prolonging circulation half-life special issue-antibody research Antibody FragmentHalf-Life ExtensionPEGylationFc FusionAntibodies are currently the fastest growing class of therapeutic proteins. When antibody fragments are ... AP Herrington-Symes,M Farys,H Khalili,... - 《Advances ...
Antibodies with improved half-life in ferretsThe antibodies, immunoglobulin constructs, or immunoglobulin fusion proteins whose in vivo half-life is increased in ferrets by a modified ferret IgG Fc region can be useful to test therapeutics in ferrets and ferret models.NESSPOR, Thomas...
The biologic half-lives of tissue-localized antibodies were calculated from data collected between the 3rd and the 27th day after intravenous administration of radioglobulins. The biologic half-life of brain-localized antibody was 7.4 days and that of spleen-localized antibody, 5.8 days. The ...