We next determined the in vivo circulating half-life of Ab#2_GLP1 in lean mice. After a single intravenous dose, the peptide-antibody fusion concentrations were quantified over time utilising capture and detection reagents specific to human Fc. As a surrogate for peptide integrity, the activity ...
Fc-less bispecific T-cell engagers have reached the immuno-oncology market but necessitate continual infusion due to rapid clearance from the circulation. This work introduces a programmable serum half-life extension platform based on fusion of human albumin sequences engineered with either null (NB)...
20. hinton pr, xiong jm, johlfs mg, tang mt, keller s, tsurushita n. an engineered human igg1 antibody with longer serum half-life. j immunol. 2006;176:346-56. (fc) 21. dong j, sereno a, aivazian d, langley e, miller br, snyder wb, et al. a stable igg-like bispecific ...
A chimeric JAA-F11 was also constructed in which the entire mouse JAA-F11 variable region was attached to a human IgG1 constant region. This provided a baseline that should have the original specificity and affinity of the mouse antibody while having the human constant region, to be used as ...
Goat / IgG 分类 Polyclonal 类型 Secondary Antibody 抗原 Purified Mouse IgG, whole molecule 偶联物 DyLight™ 488 查看其它偶联染料 激发/发射光谱 492/519 nm 查看光谱 形式 Liquid 浓度 1 mg/mL 纯化类型 Antigen affinity chromatography 保存液 PBS, pH 7.2, with 1% BSA ...
抗体名:Jackson二圄 309-065-095Biotin-SP-AffiniPure Rabbit Anti-Human IgM, Fc5μ Fragment Specific (min X Ms Sr Prot) 浓度:0.8 % 靶点:Jackson二圄 免疫原:Jackson二圄 宿主:Jackson二圄 应用范围:Jackson二圄 产地:美国 品牌:Jackson 适应物种:Jackson二圄 ...
After confirming the therapeutic efficacy of the chimeric 12G2 monoclonal antibody consisting of mouse variable regions and human IgG1 constant regions, 16 humanized 12G2 monoclonal antibody variants were generated by grafting its complementary determining regions to selected human germline sequences. ...
抗体亚型:IgG1 克隆号:10-11 荧光染料:Purified 产品介绍 技术参数 相关产品 产品介绍 产品介绍 Mouse anti Human C4d antibody, clone 10-11 recognizes the secreted protein complement component 4d (C4d). The presence of C4d in renal peritubular capillaries is a key indicator for acute antibody-mediated...
1:500-1:5,000 产品规格 种属反应 Chicken 宿主/亚型 Rabbit / IgG 分类 Polyclonal 类型 Secondary Antibody 偶联物 Biotin 查看其它偶联染料 Request custom conjugation 形式 Lyophilized 浓度 1.3 mg/mL 纯化类型 Affinity chromatography 保存液 PBS, pH 7.6, with 15mg/mL BSA ...
The three therapeutic mAbs used in this study (Cas, Imd, and Sot) have human IgG1 backbones, Cas and Imd with no modification in the Fc region, and Sot with a two amino acid modification in the Fc region that confers extended half-life. All three of these mAbs bound to FcR ...