Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dosing, frequenc
Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dosing, frequency of administration and thereby p...
Antibodies of the IgG isotype have a variety of pro- and anti-inflammatory effector functions, making them attractive platforms for the development of novel therapeutic approaches. Animal model systems have been invaluable to the understanding of the underlying mechanisms of IgG activity. However, diffe...
This would represent an important application for antibody production because different IgH subclasses (for example, IgG1 versus IgG4) are known to have different affinity for the Fc receptor, potency in complement activation, biological properties in terms of half-life and tissue diffusion, as well...
In blood, IgA is the second most abundant Ab after the IgG (Kerr, 1990; Mestecky, Russell, Jackson, & Brown, 1986; Papista, Berthelot, & Monteiro, 2011). Unlike mice who only have one type of IgA, human IgA has two subtypes: IgA1 and IgA2. The major structural difference between ...
Rocha MA, Morrison SL (2007) Human immunoglobulin G2 (IgG2) and IgG4, but not IgG1 or IgG3, protect mice against Cryptococcus neoformans infection. ... O David,Beenhouwer,M Esther,... - 《Infection & Immunity》 被引量: 95发表: 2007年 Low IgG3 and high IgG4 subclass levels in chil...
Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice. We investigated the capacity of five human monoclonal IgG anti-DNA antibodies derived from lupus patients to produce glomerular immune deposits. The hybridomas secreting these antibodies were administered intraperitoneally...
(Fig. 2B). The benefits of using full length ThAb include longer serum half-life as a result of interaction with FcRn, improved effector functionviaengagement with a range of Fc receptors, and in some cases, more effective neutralisation when compared to the correspondingFabfragment (Abboud et...
human IgG (a marker for pembrolizumab, red), and the merge of the three prior images. Immunofluorescence for human PD-1 demonstrated diffuse staining in the xenograft of nblk mice compared to absent staining in the blk mice, confirming the PD-1-blocking effect of pembrolizumab. In the contral...
Human IgG3 displays the strongest effector functions of all IgG subclasses but has a short half-life for unresolved reasons. Here we show that IgG3 binds to IgG-salvage receptor (FcRn), but that FcRn-mediated transport and rescue of IgG3 is inhibited in the presence of IgG1 due to ...