Evidence for the latter role initially came from studies indicating an unusually short serum half-life for IgG antibodies in β2m-deficient mice (9, 10, 11). This observation led to the generation of mutant mouse hinge-Fc fragments with enhanced binding to FcRn and increased serum persistence ...
The tolerogenic properties of the purified myelomatous human IgG subclasses IgG1, IgG2, IgG3 and IgG4 were investigated in mice, when given at a dose of 1 or 5 mg either, chemically nonmodified or trinitrophenylated. A complete tolerance at the helper T cell level was obtained with IgG1...
Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dosing, frequenc
Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice. We investigated the capacity of five human monoclonal IgG anti-DNA antibodies derived from lupus patients to produce glomerular immune deposits. The hybridomas secreting these antibodies were administered intraperitoneally...
Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice. We investigated the capacity of five human monoclonal IgG anti-DNA antibodies derived from lupus patients to produce glomerular immune deposits. The hybridomas secreting these antibodies were administered ...
In the present study, we performed joint scRNA-seq and snRNA-seq of intercostal muscle across the adult human lifespan. This allowed us to investigate transcriptional changes of MuSCs, MFs and microenvironment cells during aging. We discovered cell–cell interactions that may contribute to the aging...
抗体名: Mouse Anti-Human IgG, Kappa Chain Monoclonal Antibody, FITC 浓度: 1mg/ml % 宿主: Mouse 用途: 仅用于科研 应用范围: WB,IF,ELISA 纯度: 95% 产地: France 品牌: AntibodySystem 货号: MHD36941 用途: 仅用于科研 亚型: IgG1 是否单克隆: 是 免疫原: NA 保质期: 1 year...
IgG1 分子量(MW)icon 32 kDa 纯化方式(Purity)icon Protein G purified from mice ascites 公司简介 武汉科斯坦生物科技有限公司是一家致力于前沿生物技术研发与成果转化的创新型高科技企业。 公司成立以来,一直专注于生命科学研发与技术服务领域,与 高校建立合作关系,逐步建立并完善了“分离纯化平台”、“分析检测平台...
Antibodies of the IgG isotype have a variety of pro- and anti-inflammatory effector functions, making them attractive platforms for the development of nove
Here, we identify multiple rare variants in GPR10 in people with severe obesity and in normal weight controls. These variants impair ligand binding and G protein-dependent signalling in cells. Transgenic mice harbouring a loss of function GPR10 variant found in an individual with obesity, gain ...