The invention provides isolated nucleic acids that encode a human GTP-activator protein for RAE-like GTPase (GAP N) , and fragments thereof, vectors for propagating and expressing GAP N nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein ...
The Ras GTPase-activating-like protein IQGAP1 is a scaffold protein involved in the regulation of various cellular processes ranging from organization of the actin cytoskeleton, transcription and cellular adhesion to cell cycle control. Despite its name, IQGAP1 is not a GAP but stabilizes Rac1 an...
The inactivation of the p21ras-ERK pathways has been linked to the induction of T-cell nonresponsiveness or anergy32,33. The Ras protein activator-like 1 protein (Rasal1) is a member of a GAP family that includes p120 RasGAP (or Rasa1), NF134,35, and Rasa2-436,37,38. Each ...
Q8IVW1 ARL17A ADP-ribosylation factor-like protein 17 - Rab family P62820 RAB1A Ras-related protein Rab-1A 24879 Q9H0U4 RAB1B Ras-related protein Rab-1B Detected + 29632235 P61019 RAB2A Ras-related protein Rab-2A 11553 Q8WUD1 RAB2B Ras-related protein Rab-2B 7403 P20336 RAB...
Ras protein family The Ras subfamily of GTPases is part of the Ras superfamily of GTPases, named after the rat sarcoma viral oncogene. The Ras subfamily contains many Ras isoforms, including K-Ras, H-Ras, and N-Ras. While the three isoforms are ...
Rheb is a conserved and widespread Ras-like GTPase involved in cell growth regulation mediated by the (m)TORC1 kinase complex and implicated in tumourigenesis in humans. Rheb function depends on its association with membranes via prenylated C-terminus, a mechanism shared with many other eukaryotic ...
RAN GTPase 酶激活蛋白1抗体品牌 英文名称 Anti-RanGAP1 中文名称 RAN GTPase 酶激活蛋白1抗体品牌 别名 Fug 1; Fug-1; Fug1; KIAA1835; RAGP1_HUMAN; Ran 1; RAN GTPase activating protein 1; RAN GTPase-activa
Rac proteins are members of the Rho family of Ras-like small GTPases. These GTPases essentially function as switches, they are "on" in the GTP-bound and "off" in the GDP-bound state (22). In the active state, they relay signals from growth factors, cytokines, and adhesion M O L ...
In this study, we found that the putative Ras small GTPase RSR1 negatively regulated the expression of cellulases and xylanases. Deletion ofrsr1(∆rsr1) significantly increased cellulase production and decreased the expression levels of ACY1-cAMP-protein kinase A (PKA) signaling pathway genes and...
Ras mutations elsewhere, within the domain for binding effector proteins, have proven useful in addressing the requirement for the effector domain in different cellular functions: for example, amino acid substitutions that are unable to bind Raf-1 protein, such as D38N, also have reduced ...