2.上颚 β-catenin介导的Wnt信号通路涉及各种组织和器官的发育,包括颅面结构[5]。在小鼠胚胎发育过程中,Gsk-3β对于上颚形成至关重要,Gsk-3β在调节胚胎干细胞系中的Wnt/βcatenin信号传导中发挥冗余功能[6]。Gsk-3β突变杂合子的小...
2.上颚 β-catenin介导的Wnt信号通路涉及各种组织和器官的发育,包括颅面结构[5]。在小鼠胚胎发育过程中,Gsk-3β对于上颚形成至关重要,Gsk-3β在调节胚胎干细胞系中的Wnt/βcatenin信号传导中发挥冗余功能[6]。Gsk-3β突变杂合子的小鼠看起来正常且有生育能力,但通过Gsk3b+/-小鼠之间的杂交获得的Gsk3b-/-小鼠...
mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling...
在小鼠胚胎发育过程中,Gsk-3β对于上颚形成至关重要,Gsk-3β在调节胚胎干细胞系中的Wnt/βcatenin信号传导中发挥冗余功能[6]。Gsk-3β突变杂合子的小鼠看起来正常且有生育能力,但通过Gsk3b+/-小鼠之间的杂交获得的Gsk3b-/-小鼠表现出完全的腭裂缺陷并在出生后24小时内死亡。为了确定Gsk-3β在腭发生过程中的...
宿主/亚型 Rabbit / IgG 种属反应性 human, mouse and More (1) 应用 WB, IHC, IF/ICC, IP, ELISA and More (1) 别名 GSK 3 beta, GSK3 beta, GSK3A B, GSK3B, GSK-3B, GSK3B 216P, gsk3beta 缓冲液配方: PBS and Azide PBS and Azide偶联物: Unconjugated Unconjugated...
别名 GSK3 beta, GSK3A B, GSK-3 beta, GSK 3 beta, EC:2.7.11.26 计算分子量 433 aa, 48 kDa 观测分子量 46-48 kDa GenBank蛋白编号 BC000251 基因名称 GSK3B Gene ID (NCBI) 2932 RRID AB_2878997 偶联类型 Unconjugated 形式 Liquid 纯化方式 Antigen affinity purification UNIPROT ID P49841 储存...
mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling...
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell. 2009; 136:1017-1031. [PubMed: 19303846]Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, et al. Disrupted in schizophrenia 1 regulates neuronal progenitor ...
(mGSK3B) existed where exons 8 and 9 were deleted. The mGSK3Bisoformlacked the ability to bindAxinand FRAT and thus the variant kinase was ineffective in phosphorylating beta-catenin suggesting a key role for this mutant kinase in CML biology (Abrahamsson et al., 2009). Supporting this ...
GSK-3 beta/GSK3B 蛋白分子量&等电点 Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) Homo sapiens (Human). 参数根据以下信息计算得出 FT CHAIN 1-420 Glycogen synthase kinase-3 beta. ...