Glycogen synthase kinase-3 (GSK-3) inhibitors, the Wnt signaling agonists, maintain the pluripotency of embryonic stem cells. We report here that a synthetic GSK-3 inhibitor, 6-bromoindirubin-3′-oxime (BIO), showed opposite effects on the expansion of human primitive hematopoietic cells isolated...
GSK-3作⽤通路: PI3K/Akt/mTOR; Stem Cell/Wnt储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis.BIOLOGICAL ACTIVITY⽣物活性GSK-3 inhibitor 6 (2) 是具有 CNS 通透性的 GSK-3 抑制剂,其对GSK-3α 和 GSK-3β 的 IC50 值分别为 29 nM 和 24...
GSK-3β抑制剂通过wnt/β-catenin调控OPG在DKD大鼠肾组织中作用[J]. 中国公共卫生, 2019, 35(6): 738-741. DOI: 10.11847/zgggws1118646 Yi-xia ZHOU, Wen-qing YANG, Long LI, . Regulation effect of glycogen synthase kinase-3β inhibitor on osteoprotegerin-related wnt/β-catenin signal pathway ...
Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEGSK-3inhibitor7Cat.No.:HY-126201CASNo.:405221-09-2分⼦式:C₁₅H₁₅N₅O分⼦量:281.31作⽤靶点:GSK-3作⽤通路:PI3K/Akt/mTOR;StemCell/Wnt储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCerti...
同时,BIO也是泛JAK抑制剂,对Tyk2的IC50值为30 nM。作为一种丝氨酸-苏氨酸蛋白激酶,GSK 3 Inhibitor IX可以激活Wnt信号通路,有助于促进细胞增殖,维持人和小鼠胚胎干细胞保持自我更新的能力。此外,GSK 3 Inhibitor IX还可诱导人体黑色素瘤细胞凋亡。 产品性质...
GSK-3抑制剂X是BIO的乙酰肟类似物,可作为选择性GSK-3α/β抑制剂(对于GSK-3α/β,CDK5 / p25,CDK2 /,IC | 50 |值为0.01、2.4、4.3和63μM细胞周期蛋白A和CDK1 /细胞周期蛋白B)。GSK-3抑制剂X诱导Wnt信号传导并抑制CD8 + T细胞效应子的分化。
Autophagycyclin dependent kinase 1 Inhibitorglycogen synthase kinase 3 alpha Inhibitorglycogen synthase kinase 3 beta InhibitorGSK-3mitogen-activated protein kinase 1 InhibitorPI3K/Akt/mTORStem Cell/WntWntβ-catenin Skip to the end of the images gallery ...
GSK3β inhibitor II 是 GSK3β 的抑制剂。GSK3β inhibitor II 可用于研究阿尔茨海默病 (AD)。 规格价格库存数量 1 mg¥ 113现货 5 mg¥ 268现货 10 mg¥ 461现货 25 mg¥ 960现货 50 mg¥ 1,410现货 100 mg¥ 2,050现货 200 mg¥ 2,790现货 ...
GSK-3 inhibitor 1是一种有效的GSK3抑制剂。GSK-3(糖原合酶激酶3)是一种丝氨酸/苏氨酸蛋白激酶,与病理情况,如糖尿病和阿尔茨海默病(AD)相关,对细胞存活,β-连环蛋白/Wnt信号通路有影响。 产品性质 英文别名(English Synonym) 3-(2-pyridinylmethylene)-2-oxindole ...
(Zhou et al., 2014b). However, the complete role of GSK-3 is still not clearly understood. For example, in contract to ketamine administration, the GSK-3 inhibitor SB216763 did not induce a rapid antidepressant action in mice, when exposed to both acute screening tests and a chronic mild...