6. XAV-939阻断Wnt/β-catenin信号通路促进FAPs的脂肪生成 1μM XAV-939处理显著抑制了Ctnnb1的转录水平,而GSK3A和GSK3B的mRNA表达水平没有显著差异。此外,在抑制Wnt/β-catenin通路后,β-catenin的表达显著下降,与脂肪生成相关的基因和蛋白(PPARγ、C/EBPα、FABP4、DGAT)的表达增加,表明β-catenin的下调信号...
Stem Cell/Wnt——GSK-3(59) Cat. No.Product NameCAS No.PurityChemical Structure KM6588 (E/Z)-GSK-3β inhibitor 1 (E/Z)-GSK-3β inhibitor 1 是 (E)-GSK-3β inhibitor 1 和 (Z)-GSK-3β inhibitor 1 的消旋体。GSK-3β inhibitor 1 (compound 3a) 是糖原合成酶激酶 3β (GSK-3β...
GSK3 is one of the few signaling mediators that play central roles in a diverse range of signaling pathways, including those activated by Wnts, hedgehog, growth factors, cytokines, and G protein-coupled ligands. Although the inhibition of GSK3-mediated β-catenin phosphorylation is known to be...
Wnt3aGSK3catenin信号通路参与乳腺癌化疗脑发生的分子机制研究Wnt3aGSK3catenin信号通路参与乳腺癌化疗脑发生的分子机制研究一引言乳腺癌是一种全球范围内广泛存在的恶性疾病,化疗是治疗乳腺癌的重要手段之一。然而,化疗过
糖原合酶激酶 3( GSK3) 是生物体内诸多信号通路的参与者,是 Wnt 信号通路的上游作用物,对其起着关键作用。 糖尿病肾病的发生和发展机制复杂,在分子生物学上需要许多信号通路的参与。 现就 GSK3-Wnt 信号通路与糖尿病肾病的关系进行总结和讨论。关键词: Wnt 信号;糖原合酶激酶 3;糖尿病肾病The Relati......
GSK 3 β 和 β cateninmRNA 在胎鼠围生期脑缺血再灌注损伤中的变化 向龙 1 唐艺玮 1 毛萌 2 周晖 2 【摘要】 目的 探讨围生期脑缺血再灌注损伤后,不同发育期胎鼠胚脑 Wnt 信号通路关键分子糖原 合成酶激酶( GSK ) 3 β 及 β 连环蛋白( catenin ) mRNA 表达水平变化。方法 采用完全随机设计,将 40...
Furthermore, we integrate information supporting the role of the glycogen synthase kinase 3β (GSK3β) in the onset/development of ASDs through direct modulation of Wnt/β-catenin signaling. Finally, given GSK3β activity as key modulator of synaptic plasticity, we explore the potential of this...
GSK3-ARC/Arg3.1 and GSK3-Wnt signaling axes trigger amyloid-β accumulation and neuroinflammation in middle-aged Shugoshin 1 (Sgo1) miceamyloid‐βcohesinopathygenomic instabilitylate‐onset Alzheimer's diseasemitosismouse modelneuroinflammationShugoshin1...
Wnt 信号通路细胞凋亡再灌注大鼠,SD目的:探讨围生期脑缺血再灌注损伤后,不同发育期胎鼠胚脑 Wnt 信号通路关键分子糖原合成酶激酶(GSK)-3β及β-连环蛋白(catenin)mRNA 表达水平变化.方法采用完全随机设计,将40只成功受孕的雌性 SD 大鼠分为实验组及对照组,每组各20只.两组分别于孕14,16,18及20 d(分别计为...