6. XAV-939阻断Wnt/β-catenin信号通路促进FAPs的脂肪生成 1μM XAV-939处理显著抑制了Ctnnb1的转录水平,而GSK3A和GSK3B的mRNA表达水平没有显著差异。此外,在抑制Wnt/β-catenin通路后,β-catenin的表达显著下降,与脂肪生成相关的基因和蛋白(PPARγ、C/EBPα、FABP4、DGAT)的表达增加,表明β-catenin的下调信号...
而自噬标志蛋白LC3Ⅱ表达趋势与Wnt、GSK3β、β-catenin蛋白相反,于再灌注0-4H逐渐上调,R4-8H表达减弱.3)流式细胞仪检测R4-8H凋亡早中晚期逐渐增多(P<0.05).结论:在PC12细胞糖氧剥夺再灌注过程中,Wnt/GSK3β/β-catenin信号通路的激活与细胞凋亡正相关,与细胞自噬活动负相关.提示抑制Wnt/GSK3β/β-catenin...
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·论著·Wnt信号通路GSK 3β和β cateninmRNA在胎鼠围生期脑缺血再灌注损伤中的变化向龙1 唐艺玮1 毛萌2 周晖2 【摘要】 目的 探讨围生期脑缺血再灌注损伤后..
糖原合酶激酶 3( GSK3) 是生物体内诸多信号通路的参与者,是 Wnt 信号通路的上游作用物,对其起着关键作用。 糖尿病肾病的发生和发展机制复杂,在分子生物学上需要许多信号通路的参与。 现就 GSK3-Wnt 信号通路与糖尿病肾病的关系进行总结和讨论。关键词: Wnt 信号;糖原合酶激酶 3;糖尿病肾病The Relati......
七氟醚预处理对大鼠心肌缺血再灌注时wnt/GSK-3β/β-catenin信号通路的影响:离体实验 目的 评价七氟醚预处理对大鼠心肌缺血再灌注时wnt/糖原合成酶激酶-3β(GSK-3β)/β-连环蛋白(β-catenin)信号通路的影响.方法 成年健康雄性Wistar大鼠,体重220～ 280 ... 邓倩,田环环,庞昀婷,... - 《中华麻醉学杂志》...
While this pathway is known to be crucial for proper T cell development, few studies have investigated the role of the Wnt signaling pathway within effector T cells. As a first approach to interrogate the influence of this pathway on effectors T cell function, GSK3β pharmacologic inhibitors (...
Recently, regulation of Wnt signaling by naringin has been reported in different disorders. Therefore, the present study aimed to investigate the possible role of Wnt/GSK-3β/β-catenin signaling in hyperthyroidism-induced mood disturbances and explore the therapeutic effects of naringin. Hyperthyroidism...
The canonical Wnt signaling pathway is critical for development of the mammalian central nervous system and regulates diverse processes throughout adulthood, including adult neurogenesis. Glycogen synthase kinase-3 (GSK-3) antagonizes the canonical Wnt pathway and therefore also plays a central role in ...