GSK 3抑制剂IX用途 GSK 3 Inhibitor IX (6-Bromoindirubin-3'-oxime; BIO) 是一种有效的,选择性的,可逆的,ATP 竞争性的 GSK-3α/β 和 CDK1-cyclinB 复合体抑制剂,能够抑制 (GSK-3α/β)/CDK1/CDK5 的活性,IC50 值分别为 5 nM/320 nM/83 nM。
Arabidopsis GSK-3 Inhibitor; Abrasin; Arabidopsis SHAGGY-related Kinase Inhibitor; GSK-3-like Kinase BIN2 Inhibitor; 4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid; N-(5-Bromopyridin-2-yl)succinamic acid 中文名称 (Chinese Name)
BIO(又名GSK 3 Inhibitor IX)是一种细胞渗透性的、ATP竞争性的、有效的GSK-3α/GSK-3β抑制剂(IC50为5 nM),也是CDK1-cyclinB 复合体抑制剂,能够抑制CDK1/CDK5的活性,其IC50分别为320 nM/83 nM。同时,BIO也是泛JAK抑制剂,对Tyk2的IC50值为30 nM。作为一种丝氨酸-苏氨酸蛋白激酶,GSK 3 Inhibitor IX可以...
GSK-3β inhibitor 2 (Compound 3) is a potent, selective and orally active GSK-3β inhibitor with an IC50 of 1.1 nM. GSK-3β inhibitor 2 can cross the blood-brain barrier. GSK-3β inhibitor 2 has the potential for Alzheimer's disease. ChemeGen 作为优秀的抑制剂、激动剂及新型生命科学试剂...
别名Thiadiazolidinone-8, TDZD 8, GSK-3 Inhibitor I 中文名N/A 化学式C10H10N2O2S 分子量222.26 CAS号327036-89-5 纯度98% 溶剂/溶解度Water<1mg/ml; DMSO44.5mg/ml; Ethanol44.5mg/ml 溶液配制5mg加入2.25ml DMSO,或者每2.22mg加入1ml DMSO,配制成10mM溶液。SF2766-10mM用DMSO配制。
1.Attwood MM, Fabbro D, Sokolov AV, Knapp S, Schiöth HB. Trends in kinase drug discovery: targets, indications and inhibitor design. Nat Rev Drug Discov. 2021 Nov;20(11):839-861. 2.Snitow M E , Bhansali R S , Klein P S . Lithium and Therapeutic Targeting of GSK-3[J]. Cell...
产品活性:GSK-3β inhibitor 2 (Compound 3) 是一种有效,选择性和口服活性的 GSK-3β 抑制剂,IC50 为 1.1 nM。GSK-3β inhibitor 2 可以穿越血脑屏障。GSK-3β inhibitor 2 有用于阿尔茨海默氏病的潜力。 生物活性:GSK-3β inhibitor 2 (Compound 3) 是一种有效、选择性和具有口服活性的GSK-3β抑制剂...
Objective:Polycystic ovarian syndrome(PCOS)is a common reproductive disorder, and its pathogenesis has Insulin resistance(IR).To investigate the effects of GSK-3 inhibitor SB216763on expression of Glycogen synthase kinese-3β(GSK-3β)and Insulin Receptor Substrates-1(IRS-1)in Granulosa cells of ...
[GSK-3β inhibitor 11]化源网提供GSK-3β inhibitor 11CAS号536731-65-4,GSK-3β inhibitor 11MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询GSK-3β inhibitor 11上化源网,专业又轻松。
GSK-3 Inhibitor X structure CAS No. 740841-15-0 Chemical Name: GSK-3 Inhibitor X Synonyms (E/Z)-BIO-acetoxime;GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem;2H-Indol-2-one, 3-[3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro- CBNumber: CB...