To determine the effect of Wnt/b-catenin signalling on self-renewal and morphology, J1 mESCs and F9 mouse embryonal carcinoma (mEC) cells were treated with the GSK3 inhibitors BIO and CHIR. We found that both J1 mESCs and F9 mEC cells grown in the presence of 1 mM BIO or 3 mM CHIR ...
[1].SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK3 INHIBITORS: III. 20170252449 A1 GSK-3抑制剂1物理化学性质 分子式C22H17ClFN5O2 分子量437.85 PSA80.12000 LogP8.59270 储存条件2-8℃ ...
GSK-3 Inhibitors (34) GSK-3 Activator (1) New GSK-3 Products Catalog No.Product NameInformationProduct Use CitationsProduct Validations S1263Laduviglusib (CHIR-99021)Laduviglusib (CHIR-99021, CT99021) is aGSK-3αandGSK-3βinhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR9920...
MEDINA PADILLA MIGUELDOMINGUEZ CORREA JUAN MANUELDE CRISTOBAL BLANCO JAVIERFUERTES HUERTA ANASANCHEZ-QUESADA JORGELOPEZ OGALLA JAVIERHERRERO SANTOS SUSANAPEREZ DE LA CRUZ MORENO MARIA ANGELESMARTINEZ MONTERO OLGARODRIGUEZ SALGUERO BEATRIZ
GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS Front Mol Neurosci. 2011;4:32. doi: 10.3389/ fnmol.2011.00032.Eldar-Finkelman H, Martinez A. GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS... H Eldar-Finkelman,A Martinez - 《Frontiers in Molecular Neuroscience》 被引量: 197...
[2]. Meijer, L., et al. (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 10, 1255-12662. [3]. Tseng, A. S., et al. (2006) The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem Biol. 13, 957-963. ...
[1].Sivaprakasam P, et al. Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg Med Chem Lett. 2015 May 1;25(9):1856-63. HB221111...
Western blots were used to quantitate changes in autophagy-related protein expression after A549 cells were treated with GSK-3β inhibitors and after H460 cells were transfected with GSK-3β mutants with different activities and X-ray irradiated. Clonogenic assays were used to measure the effect ...
[1].Hartz RA, et al. Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-b]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors. J Med Chem. 2023 Mar 23;66(6):4231-4252. ...
GSK3 inhibitors may provide a novel treatment strategy for fatty liver disease. Discussion Excessive fat deposition in visceral adipose tissue is intimately related to the development of hepatic steatosis in obese individuals and is thought to be a key contributor to the development of FLD and FLD-...