GSK-3 inhibitorsThe disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds to treat disorders associated with GSK-3.Guanglin LuoLing ChenGene M. DubowchikSwanee E. Jacutin-Porte...
GSK-3 inhibitors (inhibiting targets of signaling pathways) used for various assays, some have entered clinical trials, which would be new cancer therapies.
[2]. Meijer, L., et al. (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 10, 1255-12662. [3]. Tseng, A. S., et al. (2006) The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem Biol. 13, 957-963. ...
GSK-3 参考文献 [1].SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK3 INHIBITORS: III. 20170252449 A1 GSK-3抑制剂1物理化学性质 分子式C22H17ClFN5O2 分子量437.85 PSA80.12000 LogP8.59270 ...
[1].Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27(9):1804-1817. doi: 10.1016/j.bmc.2019.03.028. Epub 2019 Mar 15. PMID: 30902399. ...
GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS Front Mol Neurosci. 2011;4:32. doi: 10.3389/ fnmol.2011.00032.Eldar-Finkelman H, Martinez A. GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS... H Eldar-Finkelman,A Martinez - 《Frontiers in Molecular Neuroscience》 被引量: 197...
GSK3 inhibitors may provide a novel treatment strategy for fatty liver disease. Discussion Excessive fat deposition in visceral adipose tissue is intimately related to the development of hepatic steatosis in obese individuals and is thought to be a key contributor to the development of FLD and FLD-...
Western blots were used to quantitate changes in autophagy-related protein expression after A549 cells were treated with GSK-3β inhibitors and after H460 cells were transfected with GSK-3β mutants with different activities and X-ray irradiated. Clonogenic assays were used to measure the effect ...
We also found that activation of JNK-mediated pathways in response to GSK3 inhibition contributed to the potentiation of 1,25D-induced differentiation. Taken together, our findings offer a preclinical rationale to explore the repositioning of GSK3 inhibitors to enhance differentiation-based therapy for...
Benzofuran-3-yl(indol-3-yl) Maleimides as Potent GSK3 InhibitorsCompounds of formula: and pharmaceutically acceptable salts, esters and solvates thereof, where variables are defined in the specification, useful generally as inhibitors of protein kinases and particularly useful for inhibition of GSK-3...