GSK-3 Inhibitor X CAS号: 740841-15-0 英文名: GSK-3 Inhibitor X 英文别名: (E/Z)-BIO-acetoxime;GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem;2H-Indol-2-one, 3-[3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro- 中文名: GSK-3 Inhibitor X ...
A peptide inhibitor of GSK-3 comprising a peptide having between 13 and 50 amino acid residues and an amino acid sequence represented by the formula: EPXAZ1XBZ2XC(A/S)P (SEQ ID Nos: 54-61 ), wherein XA represents 2 or 3 amino acid residues which can, independently, be any amino ...
Inhibition of autophagosome degradation by chloroquine further enhanced LC3B II expression upon treatment with GSK3 inhibitor (Fig. 1B) or in cells transduced with a shRNA targeting GSK3β (Fig. 1C) suggesting that GSK3 inhibition promotes an autophagic response in pancreatic cancer cells. ...
别名:GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime 溶解性(25°C)体外DMSO 71 mg/mL (199 mM) 水<1 mg/mL (<1 mM) 乙醇21 mg/mL (58 mM) 体内30% PEG400/0.5% Tween80/5% propylene glycol, 30 mg/mL Chemical Name: 2H-Indol-2-one,6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-...
Western blotting showed that (a) after X-ray irradiation alone, GSK-3β levels decreased; p62 and AMPK levels did not change significantly; and LC3 levels increased in A549 cells. After treatment with the GSK-3 inhibitor SB216763, p62 levels did not change significantly, whereas AMPK and LC3...
A novel GSK-3beta inhibitor YQ138 pre- vents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway. Acta Pharmacol. Sin. 37, 741-752.Pang T, Wang YJ, Gao YX, Xu Y, Li Q, Zhou YB, Xu L, Huang ZJ,...
X-linked inhibitor of apoptosis (XIAP) has been shown to bind to caspase-3, -7 and -9 resulting in inhibition of caspase activities, and to promote their ubiquitination resulting in the degradation. In the present study, we studied the involvement of GSK3 in the regulation of expression ...
Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572) Raltegravir (RAL) and related HIV-1 integrase (IN) strand transfer inhibitors (INSTIs) efficiently block viral replication in vitro and suppress viremia in... S Hare,SJ Smith,...
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InhibitorGlycogen synthase kinase-3 beta (GSK-3β) is involved in multiple signaling pathways. Consistent with its critical roles in normal cells, abnormalities in GSK-3β activity have been implicated in diabetes, heart disease, Parkinson disease and Alzheimer's disease. In this study, a series...