GSK-3 Inhibitor X structure CAS No. 740841-15-0 Chemical Name: GSK-3 Inhibitor X Synonyms (E/Z)-BIO-acetoxime;GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem;2H-Indol-2-one, 3-[3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro- CBNumber: CB...
Calcineurin and GSK-3 inhibition sen- sitizes T-cell acute lymphoblastic leukemia cells to apoptosis through X-linked inhibitor of apoptosis protein degradation. Leukemia. 2016; 30(4):812-822.Tosello, V.; Bordin, F.; Yu, J.; Agnusdei, V.; Indraccolo, S.; Basso, G.; Amadori, A.;...
别名:GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime 溶解性(25°C)体外DMSO 71 mg/mL (199 mM) 水<1 mg/mL (<1 mM) 乙醇21 mg/mL (58 mM) 体内30% PEG400/0.5% Tween80/5% propylene glycol, 30 mg/mL Chemical Name: 2H-Indol-2-one,6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-...
中文名称: GSK-3β 抑制剂 2 英文名称: GSK-3β inhibitor 2 CAS号: 1702428-31-6 品牌: TargetMol 产地: 美国 保存条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. 纯度规格: 95.69% 产品类别: 抑制剂 货号: T11471 ...
glycogensynthasekinase313rGSK.313);moleculardocking;口.carboline;synthesis;GSK.3inhibitor 1 引言 糖原合成酶激酶3D(Glycogensynthasekinase3B, GSK.313)是一种多功能的丝氨酸/苏氨酸类激酶,它在胰 岛素信号通路、Wnt和Hedgehog信号通路传导中扮演 重要的角色,通过磷酸化多种蛋白底物来参与糖原合 ...
X-linked inhibitor of apoptosis (XIAP) has been shown to bind to caspase-3, -7 and -9 resulting in inhibition of caspase activities, and to promote their ubiquitination resulting in the degradation. In the present study, we studied the involvement of GSK3 in the regulation of expression ...
In this study, we demonstrate that the GSK-3β inhibitor 6-bromoindirubin 3'-oxime (BIO) activates Wnt/β-catenin signaling, elevates the proportion of naive T cells, and delays T cell differentiation during homeostatic T cell expansion in lymphodepleted mice transplanted with human hematopoietic ...
Cell lysates—non-transfected or overexpressing EGFP-tagged proteins—were prepared in lysis buffer (20 mM HEPES, 1 mM EDTA, 0.2% Triton X-100 and protease inhibitor cocktail (Roche)) briefly sonicated (three times 5 s pulses with 30 s rest, 10 μm amplitude) and spun at 20,...
[2] TakahashiYanagaF.Activatororinhibitor?GSK3asanewdrug target[J].BiochemPharmacol,2013,86(2):191-9. [3] WatanabeM,AbeN,OshikiriY,etal.Selectivegrowthinhibi tionbyglycogensynthasekinase3inhibitorsintumorigenicHeLa hybridcellsismediatedthroughNFκBdependentGLUT3expres sion[J].Oncogenesis,2012,1:e21...
Immunofluorescence (IF) was used to analyze the effect of GSK-3β inhibitor (CHIR99021) on β-catenin and CyclinD1 expressions levels in BMSCs. A total of 428 differentially expressed miRNAs were found between the NOR and MOD groups. KEGG analysis showed that the target genes were mostly ...