GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII)是具有有效和选择性的 GSK-3β 抑制剂 ,IC50值为 64 nM。GSK-3β inhibitor 8 是一种噻吩嘧啶衍生物,负调控 Wnt 信号通路,刺激 β 细胞增殖。 规格价格库存数量 1 mg¥ 77035日内发货 大包装 & 定制 ...
Rab11a sustains GSK3beta/Wnt/beta-catenin signaling to enhance cancer progression in pancreatic cancer. Tumour biology. 2016; 37:13821-13829.Yu L, Li X, Li H, et al. Rabl la sustains GSKβ/Wnt/β-catenin signaling to enhance cancer progression in pancreatic cancer [J]. Tumour Biol, ...
GSK-3 beta 参与 Wnt 信号传导导致 CTNNB1 降解,而其 JUN 和 NFATC1/NFATC 的磷酸化则调节它们的活性。该激酶还在微管动力学中发挥着至关重要的作用,影响 MAPT/TAU 稳定性并有助于 ERBB2 依赖性微管稳定。此外,GSK-3 beta 通过与 MCL1 和 SNAI1 相互作用参与多种途径,例如 NF-kappa-B 调节、胰腺 β ...
Wnt/β-catenin agonist 2激活 Wnt/β-catenin 信号传导,是一种有效的 Wnt 激动剂。 Wnt/β-catenin agonist 2可用于与信号转导相关的疾病研究,与癌症侵袭转移密切相关。 规格价格库存数量 1 mg ¥ 516 现货 5 mg ¥ 1,170 现货 10 mg ¥ 1,990 现货 25 mg ¥ 3,280 现货 50 mg ¥...
Wnts are important regulators of dopamine (DA) neuron differentiation in the developing ventral mesencephalon and could thus serve as potential tools in the treatment of Parkinson's disease. In this study, we investigate whether established intracellular Wnt signalling components could modulate the develo...
GSK3β是在1980年做为糖原合成酶抑制分子被发现,随后发现其广泛参与了细胞增殖、干细胞更新、凋亡和及发育的过程,通过胰岛素、Wnt/β-catenin和Hedgehog等信号通路发挥作用,与神经系统紊乱、糖尿病和炎症等疾病和病理过程有着密切关系。在肾脏疾病,有报道发现GSK3β参与了肾细胞凋亡和炎症相关通路。
and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer's disease. GSK3B participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB, and the transcription facto...
Common gamma Chain Receptor Family EMT Induction Hedgehog Family IL-10 Family IL-17 Family Intracellular Kinases in the Akt Pathway Intracellular Signaling Molecules in Angiogenesis Neurofibrillary Tangle Formation Notch Pathway Wnt Intracellular Signaling...
and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer's disease. GSK3B participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB, and the transcription facto...