This chapter examines the current pipeline of novel, small molecules that target Gram-negative bacteria. Preclinical and clinical data for each compound are summarized and a critical analysis is provided. In particular, the authors evaluate how comprehensively the current unmet needs are being addressed...
Infections caused by Gram-negative pathogens are increasingly prevalent and are typically treated with broad-spectrum antibiotics, the authors noted. Gram-positive and gram-negative bacteria differ in the composition of their cell walls. Gram-negative bacteria have a double layer of protection...
Infection due to multidrug-resistant Gram-negative bacteria has become a major threat to public health1,2. The worldwide search for a truly novel class of antibiotics that can combat such bacteria and overcome antibiotic resistance has continued for the last 40 years1,2,3,4. Cationic peptides ...
Gram-negative bacteria, Gram-positive cocas resistant generally resistant, fungal resistance is low.(革兰阴性杆菌、革兰阳性球菌普遍具有耐药性,真菌耐药性较低。) RESULTS In gram-negative isolates, the antibiotics with the high resistance rate were ampicillin (86.(结果革兰阴性菌菌株对氨苄西林耐药率最高...
In the last few years a large number of new antibiotic compounds have been isolated from Gram-negative bacteria, in which very few antibiotics had been previously found. Apart from the interest of the new antibiotics themselves, this has provided new information on the distribution of antibiotics ...
Gram-negative bacilli-derived peptide antibiotics developed since 2000Gram-negative bacilliLipopeptideThiopeptideStructural sequenceAntibiotic activityBiosynthesisCell-free protein expression system is a new method to express target protein in vitro and has been widely applied to the study of protein structure...
E5 Murine Monoclonal Antiendotoxin Antibody in Gram-Negative SepsisA Randomized Controlled Trial CONTEXT: Knowledge and understanding of gram-negative sepsis have grown over the past 20 years, but the ability to treat severe sepsis successfully has not... Angus,Derek,C. - 《Journal of the ...
Conclusion Imipenem cilastatin, amikacin, ceftazidime and sulbactam cefoperazone can be used for empirical treatment of severe gram negative bacteria infection. 展开 关键词: Antibiotics Gram negative bacteria beta Lactamases 被引量: 13 年份: 1998 ...
Appreciable resistance of some isolates to the β-lactam antibiotics, erythromycin, and the tetracyclines was noted, whereas all strains were inhibited by chloramphenicol and metronidazole and almost all were inhibited by c1indamycin. The data indicate that OBS are present in infection much more often...
Antibiotics and Gram-Negative Bacteremia-Reply To the Editor.鈥 Some points in the recent article by Dr Curti (231:1361, 1975) deserve further comment.Dr Curti reviews evidence that incidence of, and survival from, Gramnegative bacteremia depend on more than antibiotic therapy. But t... JT ...