MDRGram-negative bacteriaare bacteria (or germs) that are resistant to at least three different antibiotics. These bacteria are commonly found in the gut, where they do no harm; however, they can cause infection at other body sites, mainly in patients who are vulnerable due to other underlying...
This chapter examines the current pipeline of novel, small molecules that target Gram-negative bacteria. Preclinical and clinical data for each compound are summarized and a critical analysis is provided. In particular, the authors evaluate how comprehensively the current unmet needs are being addressed...
E. Lipid A modification systems in Gram-negative bacteria. Annu. Rev. Biochem. 76, 295–329 (2007). CAS Google Scholar Kiho, T. et al. Structure–activity relationships of globomycin analogues as antibiotics. Bioorg. Med. Chem. 12, 337–361 (2004). CAS Google Scholar Download ...
Antibiotics may inhibit bacterial growth or may kill bacteria by inhibiting cell wall synthesis or protein synthesis. The amount of endotoxin released during antibiotic action has been found to be clinically important. Nine antibiotics, representing seven classes, were studied for the amounts of endotox...
Gram-staining distinguishes bacteria into two major groups,Gram-positive and Gram-negative bacteria,and has become an essential technique in microbiology.However,Gram-staining is not compatible with living cells and thus limits its applications.Here,we report the development of a polymyxin B-based fluo...
There is an urgent need for new antibiotics against Gram-negative pathogens that are resistant to carbapenem and third-generation cephalosporins, against which antibiotics of last resort have lost most of their efficacy. Here we describe a class of synthetic antibiotics inspired by scaffolds derived fr...
E5 Murine Monoclonal Antiendotoxin Antibody in Gram-Negative SepsisA Randomized Controlled Trial CONTEXT: Knowledge and understanding of gram-negative sepsis have grown over the past 20 years, but the ability to treat severe sepsis successfully has not... Angus,Derek,C. - 《Journal of the ...
Using the commonly used definition of multi drug resistance (MDR) as an organism being resist- ant to three or more classes of antibiotics [18], all seven E.coli isolates were identified as MDRs. All seven isolates were confirmed to be ESBL producers by the combined disc test while one ...
As the prevalence of resistance to some commonly prescribed antibiotics increases, particularly among gram-negative pathogens in critically ill patients, empiric combination therapy has become very important in clinical practice. As a result, the likelihood of selecting adequate empiric coverage by using ...
The current need for novel antibiotics is especially acute for drug-resistant Gram-negative pathogens1,2. These microorganisms have a highly restrictive permeability barrier, which limits the penetration of most compounds3,4. As a result, the last class of antibiotics that acted against Gram-negative...