This chapter examines the current pipeline of novel, small molecules that target Gram-negative bacteria. Preclinical and clinical data for each compound are summarized and a critical analysis is provided. In particular, the authors evaluate how comprehensively the current unmet needs are being addressed...
Conclusion Imipenem cilastatin, amikacin, ceftazidime and sulbactam cefoperazone can be used for empirical treatment of severe gram negative bacteria infection. 展开 关键词: Antibiotics Gram negative bacteria beta Lactamases 被引量: 13 年份: 1998 ...
and so “… compounds that indiscriminately kill Gram-negative bacteria would be expected to induce significant gut dysbiosis.” For example, they point out, colistin, one of the few gram-negative-only antibiotics approved for clinical use, can causeC. difficile...
Gram-negative bacteria: Incidence, epidemiology and resistance to antibiotics 来自 ResearchGate 喜欢 0 阅读量: 20 作者: A Philippon 摘要: Objective: To assess the effects of antibiotic therapy on the symptomatology, microbiology and outcome from Pseudomonas aeruginosa ventilator associated pneumonia (VAP)...
bacteria have thicker cell walls than Gram-negative bacteria, antibiotics can easily get access to thepeptidoglycan. This is however not feasible for Gram-negative bacteria because unlike Gram-positive bacteria, Gram-negative bacteria have anouter membranewhich serves as a protective layer and is...
In the last few years a large number of new antibiotic compounds have been isolated from Gram-negative bacteria, in which very few antibiotics had been previously found. Apart from the interest of the new antibiotics themselves, this has provided new information on the distribution of antibiotics ...
Special Issue "Antibiotic Resistance in Gram Negative Bacteria: An Increasing Issue in Human Health" A special issue of Antibiotics (ISSN 2079-6382). Deadline for manuscript submissions:30 September 2022 01 Special Issue Editors 02 Special Issue Information ...
There is an urgent need for new antibiotics against Gram-negative pathogens that are resistant to carbapenem and third-generation cephalosporins, against which antibiotics of last resort have lost most of their efficacy. Here we describe a class of synthetic antibiotics inspired by scaffolds derived fr...
membranethat makes them resistant to the action oflysozymes. Because of this additional layer of defence, they represent a special challenge to the hostimmune system. Here we review the mechanisms used to recognize Gram-negative bacteria as microbial agents and to distinguish them from other ...
By necessity, antibiotics are frequently and indiscriminately prescribed. The consequence of this practice has been the continuing emergence of Gram-positive and Gram-negative pathogens that have increasing antibiotic resistance. The clinical impact of antibiotic resistance in Gram-positive bacteria (e.g....