Postoperative surgical site infection (SSI) is common in open long bone fractures, so early administration of prophylactic antibiotics is critical to prevent SSI. However, the necessity of initial broad-spectrum coverage for Gram-positive and -negative pathogens remains unclear. The purpose of this ...
Researchers have identified a new class of antibiotics that works by blocking the transportation of lipopolysaccharide (LPS) to the outer membrane of the gram-negative bacteriumAcinetobacter baumannii. The most advanced member of the class, zosurabalpin (RG-6006, Roche AG), was effective against mu...
Empiric choice of gram-negative antibiotics included ceftazidime/avibactam in 9 (12%) episodes, meropenem in 38 (50.7%) episodes, piperacillin/tazobactam in 15 (20%) episodes, and an anti-pseudomonal cephalosporin in 32 (42.7%). Twenty (26.7%) received 2+ empiric anti-pseudomonal antibiotics....
S. maltophiliais an emerging pathogen responsible for hospital-acquired infections in patients previously exposed to carbapenems or other broad-spectrum antibiotics [117,118]. Its intrinsic multidrug resistance phenotype involves several chromosomal determinants. First, the species expresses various efflux sys...
Fluoroquinolone antibiotics: properties of the class and individual agents. The development of future agents with better gram-positive activity, improved gram-negative coverage, and activity against unusual pathogens such as Chlamydia ... C Stratton - 《Clinical Therapeutics》 被引量: 73发表: 1992年 ...
In the 1960s, almost all patients who developed gram-negative bacteremia during granulocytopenia died; death occurred before blood culture results were available in about 50% of cases; many patients received antibiotics that were, at best, suboptimal and frequently inactive against the invading pathog...
As the prevalence of resistance to some commonly prescribed antibiotics increases, particularly among gram-negative pathogens in critically ill patients, empiric combination therapy has become very important in clinical practice. As a result, the likelihood of selecting adequate empiric coverage by using ...
coverage7. Alkynyl-bisbenzimidazole compounds contain long hydrophobic alkynyl linkers that may interact with the outer membrane of Gram-negative bacteria, therefore combination efficacy with membrane active antibiotics was investigated. In a high throughput single point synergy screen four compounds showed ...
we demonstrate two-color imaging of Gram-positive and Gram-negative bacteria in various kinds living microbiotas,including mouse gut,human oral,soil,and crude oil microbiotas,with high selectivity and coverage.Finally,a pilot use of the probes in staining bacteria on heat-fixed sputum smear was ...
2. Ecdc. PRESS RELEASE Resistance to last-line antibiotics continues to cause concern in Europe. 2014. Available from: www.ecdc.europa.eu. Cited 2020 May 19. 3. Nordmann P, Naas T, Poirel L. Global spread of carbapenemase producing Enterobacteriaceae. Emerg Infect Dis. 2011;17(...