365: Evaluation of Empiric Dual Gram-Negative Antibiotic Coverage for Suspected Ventilator-Associated Pneumonia in the Intensive Care Unit At A Rural, Academic Medical CenterIntroduction: Many societies including IDSA and ATS recommend dual gram-negative (GN) antibiotic cov...
Stewardship personnel, including pharmacists, have a vested interest in the antibiogram because of its potential impact on antibiotic prescribing. For this reason, stewardship pharmacists often work with the microbiology laboratory to populate susceptibilities, validate the data, and format the antibiogram...
#' @param ab_transform a character to transform antibiotic input - must be one of the column names of the [antibiotics] data set: `r vector_or(colnames(antibiotics), sort = FALSE, quotes = TRUE)`. Can also be `NULL` to not transform the input. #' @param syndromic_group a column...
The Prevalence and Antibiotic Resistance Pattern of Gram-Negative Pathogens Isolated from Inanimate Hospital Sources in A Maternity Centre in Lagos State, ... Background: Antibiotic resistance Gram-negative bacteria are becoming responsible for the increased morbidity and mortality, particularly in hospitali...
J. Antibiotic resistance ABC-F proteins: bringing target protection into the limelight. ACS Infect. Dis. 4, 239–246 (2018). Article CAS PubMed Google Scholar Leclercq, R. & Courvalin, P. Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification. ...
Adequacy of empiric coverage for Gram-negative bacteremias in an adult population Purpose: This study reviewed Gram-negative bacteremias for appropriateness of antibiotic therapy at three points in time: 1) prior to Gram-stain results, 2... N Nemecek,N Bohm - American College of Clinical Pharm...
A study by Australian microbiologists at Queensland, Melbourne and Griffiths universities has shown that the candidate neurodegenerative disease drug PBT-2, combined with a polymyxin antibiotic, induced potent antimicrobial activity against polymyxin-resistant gram-negative pathogens. ...
[3]. In such situations, the timely administration of adequate antibiotic coverage is a crucial determinant of patient outcome, especially when criteria for severe sepsis are present [4]. Nevertheless, alarming resistance rates are now reported worldwide, and rising trends may elicit concerns for ...
The secondary outcomes were 28-day mortality; 28-day ICU-free days; 28-day ventilator-free days; proportions of antipseudomonal agents and anti-MRSA agents as initial antibiotic therapies; coverage rate of initial antibiotic therapies; de-escalation rate; antibiotic therapy days; and adverse events...
As to therapy, the fundamental approach with presumed gram-negative bacteremia is the prompt institution of empiric antibiotic therapy when fever first develops in the setting of granulocytopenia. There is a short "window of opportunity" after which no therapy will be effective. Combinations of ...