Using inverse probability of treatment-weighted models based on propensity scores adjusting for potential clinical confounders, we compared outcomes of those transitioned to oral antibiotics with those who continued intravenous (IV) therapy for the duration of treatment. Primary endpoints were mortality, ...
P-893. Expedited Transition to Oral Antibiotics in Gram Negative Bacteremia Reduces Hospital Length of Stay doi:10.1093/ofid/ofae631.1084BACKGROUND. Uncomplicated Gram-negative bloodstream infection (GN-BSI), often originating from the urinary tract, is a common reason for hospitalization in the ...
Previous studies have shown that kanamycin, neomycin, and paromomycin are relatively inactive against gram-negative anaerobic bacilli. However, there were differences noted between the drugs that had implications in terms of: (1) oral therapy with aminoglycosides; (2) likelihood of anaerobic or other...
Conclusion Imipenem cilastatin, amikacin, ceftazidime and sulbactam cefoperazone can be used for empirical treatment of severe gram negative bacteria infection. 展开 关键词: Antibiotics Gram negative bacteria beta Lactamases 被引量: 13 年份: 1998 ...
Infections caused by Gram-negative pathogens are increasingly prevalent and are typically treated with broad-spectrum antibiotics, resulting in disruption of the gut microbiome and susceptibility to secondary infections1,2,3. There is a critical need for antibiotics that are selective both for Gram-nega...
Abstract Gram-negative bacteria are nonfermentative and opportunistic and are among the most important causes of nosocomial infections. These bacteria, especiallyPseudomonas aeruginosa,Acinetobacter baumanniiandEscherichia coli, are resistant to various antibiotics worldwide. This level of antibiotic resistance ...
5 Patients in the ICU are among the largest consumers of antibiotics in the hospital because they are at an increased risk for infection owing to underlying conditions, impaired immunity, and exposure to multiple invasive devices.6 Several studies found that 50% to 70% of patients in the ICU ...
Oral colonisation by antimicrobial-resistant Gram-negative bacteria among long-term care facility residents: Prevalence, risk factors, and molecular epidem... Oral colonisation by antimicrobial-resistant Gram-negative bacteria among long-term care facility residents: Prevalence, risk factors, and molecular ...
Another basic approach to infection prevention has been to suppress gram-negative bacilli colonizing the alimentary canal with oral nonabsorbable antibiotics or, more recently and more effectively, with agents such as the fluoroquinolones which, unlike previous regimens, do not concurrently suppress the ...
and other non-fermentative gram-negative bacilli.1,5 Their intrinsic resistance is due to their outer membrane impermeability. Acquired resistance to this drug class is due to four mechanisms: modification of the antibiotic target, inactivation of the antibiotics, reduction of outer memb...