UV light exposure induces cutaneous inflammation and neutralizes cutaneous antioxidants. Gr-1(+)CD11b(+) myeloid cells are heterogeneous bone marrow-derived cells that promote inflammation-associated carcinogenesis. Reduced activity of catalase, an antioxidant present in the skin, has been associated ...
流式细胞分析和免疫荧光染色技术确定 2 组小鼠脾脏和脊髓组织中Gr-1+CD11b+MDSC的数量变化,体外细胞共培养检测来自 EAE 小鼠的 Gr-1+CD11b+MDSC 对 CD4+T 细胞及 CD8+T 细胞体外增殖能力的影响。结果 EAE 造模成功率为 80%(12/15),HE 染色显示炎症细胞广泛浸润于 EAE 小鼠脊髓组织,Luxol 快蓝染色在炎性...
Interferon Regulatory Factor-8 Modulates the Development of Tumor-Induced CD11b+Gr-1+ Myeloid Cells. Stewart TJ,Greeneltch KM,Reid JE, et al. Journal of Cellular and Molecular Medicine . 2009Stewart TJ, Greeneltch KM, Reid JE, et al. Interferon regulatory factor-8 modulates the ...
CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress. J Immunol. 2006;176:2085Y2094.Makarenkova, V. P., V. Bansal, B. M. Matta, L. A. Perez, and J. B. Ochoa. 2006. CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic ...
Studies have shown that bone marrow-derived cells play an important role in tumor recurrence after chemotherapy and radiotherapy. In this study, we examined the relationship between the accumulation of Gr-1+CD11b+ cells and tumor recurrence after irradia
SE and SD groups were statistically significant(P<0. 05 and P<0. 01). Conclusions:Low dose of dexamethasone can inhibit the production and accumulation of MDSCs in septic mice induced by LPS.%目的::观察小剂量地塞米松对脂多糖(LPS)诱导的脓毒症小鼠CD11b+Gr-1+髓源抑制性细胞(MDSCs)...
Since MDSCs are involved in a wide range of acute and chronic processes, several murine models have been developed to study the role of those cells. In many cases, mice are sacrificed to measure CD11b+ GR-1+ cells in the blood, spleen or other organs and the suppressive function of the...
CD11b + 外周血单核细胞发现 它们均为Gr-1 + 。我们推测肿瘤组织释放趋化因子使骨髓中未成熟单核细胞 (F4/80 + CD11b + Gr-1 + 细胞)入血,并阻碍其进一步分化成熟,使其丧失单核/巨 噬细胞的杀肿瘤细胞功能,成为肿瘤相关巨噬细胞(tumorassociated ...
ONO-4641-expanded CD11b+Gr-1+ cells showed higher arginase-1 activity, decreased T cell proliferation, and lower IFN-纬 production in CD3+ T cells, similar to the features of myeloid-derived suppressor cells. ONO-4641 treatment decreased airspace enlargement in elastase-induced and cigarette ...
Polymicrobial sepsis alters the adaptive immune response and induces T cell suppression and Th2 immune polarization. We identify a GR-1(+)CD11b(+) population whose numbers dramatically increase and remain elevated in the spleen, lymph nodes, and bone marrow during polymicrobial sepsis. Phenotypically...