Isolate highly purified mouse MDSCs (CD11b+Gr1+) from splenocytes, bone marrow, or peripheral blood in as little as 18 minutes with EasySep™.
Generation of B7H1-expressing CD11b + Gr1 + myeloid derived suppressor cells (MDSCs) during immune-modulatory therapy for \\{B16F10\\} melanomaMyeloid derived suppressor cells (MDSC) comprise a heterogeneous population of cells (CD11b + , Gr-1 + ) that can be found in tumor-...
Gr1(int)CD11b(+) cells are called myeloid-derived suppressor cells (MDSC) and play a major role in regulation of inflammation in many pathological conditions. Although MDSC have been described primarily in cancer their function in tuberculosis remains unknown. During M. tuberculosis infection it is...
肿瘤微环境中F480CD11bGr1单核细胞活化机制的研究 华中科技大学 博士学位论文 肿瘤微环境中F4/80+CD11b+Gr-1+单核细胞活化机制的研究 姓名:*** 申请学位级别:博士 专业:生物化学与分子生物学 指导教师:**化 2010-05华中科技大学同济医学院博士研究生学位论文 +...
The CD11b+ Gr1dim cells were induced from M-MDSCs with GM-CSF in vitro and were considered tolerogenic because they suppressed T-cell proliferation. The CD11b+ Gr1dim cells have never described previously and termed CD11b+ Gr1dim tolerogenic dendritic cell-like cells (CD11b+ Gr1dim tolDC-...
Tumor-associated factors are related to increased accumulation of CD11b+Gr1+myeloid-derived suppressor cells (MDSCs). However, the exact mechanism of how genetic factors control the expansion of MDSCs in tumor-bearing hosts remains elusive. Herein, we found that tumor-associated MDSCs and their ...
采用小鼠4T1乳腺癌模型观察MSC通过CD11b+Gr1+细胞对肿瘤生长的影响.结果 MSC能够促进骨髓中CD11b+Gr1+细胞的存活和生成,同时可诱导正常小鼠骨髓中CD11b+Gr1+细胞对T细胞的抑制作用.动物实验结果显示,MSC处理后的骨髓CD11b+Gr1+细胞可以促进肿瘤的生长,加速小鼠的死亡.结论 MSC可以通过促进骨髓来源的CD11b+Gr1+细胞...
The cells were also examined for the expression of F4/80, which is not expressed by neutrophils.10,11 Although the neu- trophils were F4/80 − , the Gr1int cells were F4/80 + . Collectively, the features of the Gr1int cells resembled those of myeloid- derived suppressor cells (MDSCs...
MDSCs are a phenotypically and functionally heterogeneous population categorized by their ability to functionally suppress T cell activity in cancer patients and tumor-bearing mice6,10. In mice, MDSCs are phenotypically CD11b+Gr1+like neutrophils and monocytes during homeostasis and classified as either...
Here we show that CD11b + Gr-1+ cells are expanded in the spleens, but not bone marrow, of mice infected with HV-68, consistent with the phenotype of MDSC (Figures. 1 and 2). Approximately two thirds of these cells had a Gr1+ Ly6G + phenotype, giving these cells a gra...