Antigen-specific,MHC-restricted CTLs were generated when DC/gps were used to prime T cells both in vitro and in vivo. Thus,these CTLs were cytolytic for gp100-transfected syngeneic (H-2b) tumor MCA106 (MCA/gp) and vaccinia-pMel17/gp100-infected syngeneic B16 and MCA106,but no...
A DNA vaccine has been analyzed here against malignant melanoma encoding gp100/pmel17, a melanoma-associated antigen. A small animal model was used by injection of B16 melanoma cells to syngeneic C57Bl/6 mice. DNA vaccination before tumor cell challenge leads to about 50% reduction of...