GP100-SPECIFIC T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USEThe invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino...
In situ identification of already published MART-1/ Melan-A and gp100-specificT-cell receptor [beta]-chain genes in tumor-infiltrating lymphocytes of 12 MART-1/Melan-A and gp100-expressing melanoma specimens from 3 non-HLA-A2 patients: evidence for organ specific CDR3 region expres...
The chemokine RANTES has been studied as a vaccine adjuvant in cancer therapy, but specific applications remain to be determined. For gene-based vaccination against B16 melanoma in C57BL/6JNarl mice, initial priming with mouse RANTES cDNA followed 24 h later by human gp100 DNA vaccination, ...
L. Murine dendritic cells transfected with human GP100 elicit both antigen-specific CD8(ϩ) and CD4(ϩ) T-cell responses and are more effective than DNA vaccines at generating anti-tumor immunity. Int. J. Cancer, 83: 532-540, 1999....
The gp100-specific CTL clones were found to be significantly more sensitive to the culture conditions than the MART-1/Melan-A-specific CTL clones. In addition, the presence of excess peptide in the culture medium induced autokilling of the gp100-specific, but not the MART-1/Melan-A-...
DSPIC33FJ256GP710A-I/PF Application-Specific Integrated Circuit TQFP-100(14X14) DSPIC33 No reviews yet Shenzhen Haoxinsheng Technology Co., Ltd.4 yrsCN Previous slideNext slide Previous slideNext slideOther recommendations for your business DSPIC30F4012-30I/SP Integrated Circuits Chip DS...
GP100-specific T cell receptors and related materials and methods of useThe invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino...
Mairhofer DG, Ortner D, Tripp CH, Schaffenrath S, Fleming V, Heger L, et al. Impaired gp100-Specific CD8(þ) T-cell responses in the presence of myeloid-derived suppressor cells in a spontaneous mouse melanoma model. J Invest Dermatol 2015;135:2785-93....
The present disclosure relates to the treatment of cancer, particularly gp100 positive cancers. In particular, it relates to a dosage regimen for a T cell redirecting bispecific therapeutic comprising a targeting moiety that binds the YLEPGPVTA-HcLA-A2 complex fused to a CD3 binding T cell ...
The present invention relates to the treatment of cancer, particularly gp100 positive cancers. In particular, it relates to a dosage regimen for a T cell redirecting bispecific therapeutic comprising a targeting moiety that binds the YLEPGPVTA-HLA-A2 complex fused to a CD3 binding T cell ...