GP100-SPECIFIC T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USEThe invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino...
In-vivo gp100-specific Cytotoxic CD8+ T Cell Killing Assay Cytotoxic T cells细胞毒T细胞CD8 T cellsCD8 T细胞In vivo killing assay体内杀伤实验Antigen specific CTL抗原特异性CTLTumor immunity M Benkhoucha,N Molnarfi,E Belnoue,... - BIO-PROTOCOL 被引量: 0发表: 2018年 Tumor Regression and ...
The gp100-specific CTL clones were found to be significantly more sensitive to the culture conditions than the MART-1/Melan-A-specific CTL clones. In addition, the presence of excess peptide in the culture medium induced autokilling of the gp100-specific, but not the MART-1/Melan-A-...
The chemokine RANTES has been studied as a vaccine adjuvant in cancer therapy, but specific applications remain to be determined. For gene-based vaccination against B16 melanoma in C57BL/6JNarl mice, initial priming with mouse RANTES cDNA followed 24 h later by human gp100 DNA vaccination, ...
Product Name:melanocyte lineage-specific antigen gp100 Synonyms:melanocyte lineage-specific antigen gp100 CAS: MF: MW:0 EINECS: Mol File:Mol File Information Error Report Your Email: Browse by provincemelanocyte lineage-specific antigen gp100SuppliersGlobal suppliers ...
In situ identification of already published MART-1/ Melan-A and gp100-specificT-cell receptor [beta]-chain genes in tumor-infiltrating lymphocytes of 12 MART-1/Melan-A and gp100-expressing melanoma specimens from 3 non-HLA-A2 patients: evidence for organ specific CDR3 region expres...
The engineered TCR portion of the drug targets the gp100 peptide 280-288 antigen, which is over-expressed and presented by HLA-A2 on the surface of melanoma cells, thereby effectively coating these cells with CD3-specific antibody fragments. The anti-CD3 scFv portion captures and redirects T ...
Establishment of gp100 and MART-1/Melan-A-specific cytotoxic T lymphocyte clones using in vitro immunization against preselected highly immunogenic melanom... Kirkin AF, Thor Straten P, Hansen MR, Barfoed A, Dzhandzhugazyan KN, Zeuthen J (1999) Establishment of gp100 and MART-1/Melan-A-spe...
Immuniza- tion with hgp100-expressing viral vectors overcame self- tolerance to mouse gp100 in C57BL/6 mice because the approach could induce hgp100-specific and murine B16 melanoma-cross-reactive T-cell responses.5–7 Furthermore, a number of cytokines (interleukin (IL)- 2, -12, -15, ...
GP100-specific T cell receptors and related materials and methods of useThe invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino...