The envelope glycoprotein complex (GP) is exposed on the surface of the virus as trimeric spikes and is the main target for antibody-based therapeutics and vaccine design. Initially, the glycoprotein open reading frame (ORF) codes for an immature precursor polyprotein (referred to as GPC)6. A...
We found that the footprints of the 241/289-dependent rabbit mAbs on BG505 SOSP.664 trimer are distinct from the CP506 lineage NAbs (Figure 4A; Videos S2 and S3). This was further supported by the competition ELISA analysis in which no competition was observed between the competitor 10A ...
Disulfide-linked GP1 and GP2 comprise the spikes on the virions that are also present in the Ebola-infected preparation (B). The immunoprecipitation of GPs with 13F6 was identical to that observed with MAbs 6D8 and 12B5. MAb 6D3 had reactivities identical to MAb 13C6. GP proteins were ...
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In spontaneously epileptic rats (SERs), Hanaya et al. [40] found low SV2A expression, particularly in the frontal and entorhinal cortices and the inner molecular layer and dentate gyrus of the hippocampal formation. SERs are characterized by a double mutation (zi/zi,tm/tm) which causes tonic...
300–500 of the trimeric HA spikes are present on typical influenza virus particles, in ~5-fold copy number excess over the other surface protein, neuraminidase, which has an essential sialidase activity needed to release newly budded virions from the cell surface [30,61,62]. Multivalent ...