The emergence of mRNA vaccines for SARS-CoV-2 has opened a new page in vaccine development. Nevertheless, concerns of experts have been expressed about unintentional side effects on the gut microbiota (GM). Previous studies showed that this virus acts as a bacteriophage, which infects and destro...
SARS-CoV-2 has a zoonotic origin and was transmitted to humans via an undetermined intermediate host, leading to infections in humans and other mammals. To enter host cells, the viral spike protein (S-protein) binds to its receptor, ACE2, and is then processed by TMPRSS2. Whilst receptor ...
1.An infectious bronchitis virus (IBV) spike protein or an immunogenic fragment thereof comprising a receptor-binding domain, wherein said spike protein consists of an IBV S1 protein or an immunogenic fragment thereof of the IBV S1 protein; and wherein said IBV spike protein or said immunogenic...
28 Long-lasting persistence of the spike protein in humans has been detected in immune cells (at least 15 months)29 and in the blood plasma (at least 12 months).30 However, the distribution of the spike protein in different organs, tissues, or regions of the body and its functional ...
Use as much broad-spectrum protection as you feel is necessary from the list below. List of Supplements Believed to Lessen or Prevent Continued Damage from the Spike Protein: (not in any specific order): 1.Vital basics: Immune-Priming Vit C ...
Pathological examination showed gross morphological pathological changes in the gut, including significant villus atrophy and shedding of the infected piglets. These results indicated that a 4-aa insertion in the COE region of the S protein may have partly altered the profiles of VN antibodies and ...
One way to augment protein-based vaccines is with potent adjuvants that improve the magnitude and durability of humoral and cellular immunogenicity11. Based on our previous studies using a combination of different adjuvants in HIV and cancer vaccines12,13, we investigated the effects of different ...
The structural organization of SARS-CoV-2 genome.(A)Schematic representation of SARS-CoV-2 genome organization where, bp: base pair; ORF: Open reading frame; S: Spike protein; E: Envelope protein; M: Membrane protein; N: Nucleocapsid protein.(B)The structural features of SARS-CoV-2(C)S1...
If a match is found, the algorithm looks for a crystal structure of the protein in the PDB and if coordinates are found for at least 75% of the protein sequence (75% sequence coverage), the surface accessibility is calculated. Subsequently, the accessibility is compared with a completely ...
The SARS-CoV-2 Spike protein mediates docking of the virus onto cells prior to viral invasion. Several cellular receptors facilitate SARS-CoV-2 Spike docking at the cell surface, of which ACE2 plays a key role in many cell types. The intermediate filamen