However, our understanding of the exact status of glycolytic metabolism as well as genes that regulate glycolytic metabolism are still incomplete. Sall4 is a zinc finger transcription factor that is highly expressed in undifferentiated cells in developing mouse embryos, such as blastocysts and the ...
近日,来自中国科学技术大学的研究者们在J Exp Clin Cancer Res杂志上发表了题为“METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression”的文章,该研究结果表明,METTL16/SOGA1/PDK4轴可能是治疗结直肠癌的有效靶点。 糖酵解是癌症的关键标志,并维持恶性肿瘤的发生和发展。N6-甲基腺苷...
ECAR率可以间接表示细胞糖酵解能力,从中可以看出,敲低FTO后,细胞的ECAR率有显著下降,说明敲低FTO可以使细胞糖酵解能力降低。通过富集分析可知,FTO敲低后,糖酵解通路相关基因的表达有下调。而后,进一步运用qPCR和Western Blot实验检测糖酵解相关酶、转录因子以及蛋白的表达量,发现三者的表达量在FTO敲低的细胞中都有...
Significance Of Glycolytic Metabolism-related Protein Expression In Colorectal Cancer, Lymph Node And Hepatic Metastasis 作者: Longatto-Filho, Adhemar;Viana-Pereira, Marta;Silva, Patricia;Baltazar, Fatima;Alves Costa, Ricardo Filipe;Pinheiro, Celine;Alves, Sara;Martins, Sandra Fernandes;Reis, Rui Manuel...
Analyzing metabolism of peripheral blood mononuclear cells (PBMCs) provides key opportunities to study the pathophysiology of several diseases, such as type 2 diabetes, obesity and cancer. Extracellular flux (XF) assays provide dynamic metabolic analysis of living cells that can capture ex vivo ...
On the other hand, it is known that the metabolic reprogramming with augmented glycolytic metabolism and enhanced proliferative capability is a characteristic of prostate cancer cells. The present study investigated the influence of RGN on the glycolytic metabolism of rat prostate by comparing transgenic...
Ablation of REGγ increases the stability of PP2Ac (protein phosphatase 2 catalytic subunit) in vitro and in vivo, which dephosphorylates PRAS40 (AKT1 substrate 1) and stabilizes the interaction between PRAS40 and Raptor to inactive mTORC1-mediated hyper-glycolytic metabolism. In the DEN-induced ...
Food bioactive components that affect various aspects of metabolism may be important tools to reverse glycolytic to oxidative metabolism and enhance sensitivity to apoptosis. The success of such a strategy may depend on several actors, acting in concert. Growth cofactors may be one of these, which ...
Define glycolytic. glycolytic synonyms, glycolytic pronunciation, glycolytic translation, English dictionary definition of glycolytic. n. A metabolic process that occurs in nearly all living cells in which glucose is converted in a series of steps to pyr
1,2. This dynamic and intimate crosstalk between cellular metabolism and immune cells has resulted in the emergence of the research field that is called immunometabolism1,2. Dysregulation of immunometabolic pathways was shown to play a critical role in the development and progressi...