This chapter discusses the effect of calcium and nickel ions on oxidative and glycolytic metabolism in the perfused rat heart. The study discussed in the chapter was designed to analyze changes in tissue NADH fluorescence at various extracellular Ca levels in parallel with contractile activity, oxygen...
CELL metabolismPATHOLOGICAL physiologyOBESITYTYPE 2 diabetesAnalyzing metabolism of peripheral blood mononuclear cells (PBMCs) provides key opportunities to study the pathophysiology of several diseases, such as type 2 diabetes, obesity and cancer. Extracellular flux (XF) assays provide dynamic metabolic ...
J. (1966) Relationship of glycolytic and oxidative metabolism to particle entry and destruction in phagocytosing cells. Nature 211, 1272-6.Selvaraj RJ, Sbarra AJ. Relationship of glycolytic and oxidative me- tabolism to particle entry and destruction in phagocytosing cells. Na- ture 1966;17:...
Tumour cells have long been considered defective in mitochondrial respiration and mostly dependent on glycolytic metabolism. However, this assumption is currently challenged by several lines of evidence in a growing number of tumours. Ovarian cancer (OC) is one of the most lethal cancers worldwide, ...
3g). A possible explanation for this observation is that ribose-5-phosphate in G6PDH-null chondrocytes is generated by reversal of the non-oxidative arm of the PPP (non-oxPPP), which results in the conversion of glycolytic intermediates (fructose-6-P and glyceraldehyde-3-P) into ribose-5-...
An enhanced activity of PKC causes an overproduction of ROS via blocking the glycolytic enzyme GAPDH, which stimulates the availability of triose phosphate to create DAG [118]. PKC activation causes endothelial dysfunction, increases vascular permeability, and inhibits angiogenesis through a variety of ...
reported that NQO1 overexpression in BCCs promoted glucose metabolism and metastatic potential. NQO1 could bind to liver-type pyruvate kinase (PKLR), which activates the AMP-activated protein kinase (AMPK) and AKT/mTOR signaling pathway, and ultimately induce glycolytic reprogramming and EMT in breast...
[20]. An important role of HIF-1 is to establish the optimal balance between glycolytic and oxidative metabolism at any oxygen concentration to maximize ATP production without increasing ROS levels. Thus, HIF-1 induces metabolic reprogramming in cells that are oxygen deprived, thereby reducing ...
This variation could be explained by the differential expression of metabolic-related enzymes (glycolytic vs. oxidative metabolism) as observed between astrocytes and neurons6,63. As a consequence, this may influence how the metabolites trigger cellular and metabolic response in specific cell types. A...
Altered glucose metabolism is an important feature of cancer cells, which metabolize glucose mainly through glycolysis, with mitochondria being reprogrammed for macromolecular synthesis10, 11. Enhanced glucose consumption triggered by p38α activation, can be due to increased demand for glycolytic ...