In summary, the current study revealed that human tau played an important role in regulating glycolytic metabolism under acute hyperglycemia conditions, which is similar with the Warburg effect, through influencing the homeostasis of protein-membrane association....
In this study, we presented evidence that miR-30d functions as a tumor-suppressive molecule, directly or indirectly targeting key glycolytic genes independent of oncogenic transcription factors HIF1a and MYC, and rewiring the cellular metabolism to reduce glycolysis and repress PDAC tumorigenesis. The i...
Krawczyk, C.M. et al. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation.Blood115, 4742–4749 (2010). CASPubMedPubMed CentralGoogle Scholar Hsu, P.P. & Sabatini, D.M. Cancer cell metabolism: Warburg and beyond.Cell134, 703–707 (2008). ...
The fibroblasts then undergo cellular catabolism, which results in a loss of mitochondrial function and ultimately a switch from aerobic metabolism to glycolysis [49]. This glycolytic switch results in increased lactate production by CAF, which is then exported into the extracellular space by ...
This abnormal glucose metabolism is named the Warburg effect, which plays a key role in the incidence of tumor. The Warburg effect is that, under aerobic condition, attenuating aerobic respiration of tumor cells via a series of molecular mechanisms, and exhibiting higher glycolysis metabolism and ...
In addition to the dysregulation of GLUT expression affecting the reprogramming of glycolytic metabolism in tumor cells, which results in chemoresistance, the crosstalk between tumor cells and the tumor microenvironment must not be overlooked. This crosstalk forms a signaling network that offers new insig...
In support of this idea, unbiased proteomic analysis and transcriptional profiling of a new model of cancer-associated fibroblasts (caveolin-1 (Cav-1) deficient stromal cells), shows the upregulation of both (1) myo-fibroblast markers and (2) glycolytic enzymes, under normoxic conditions. We ...
In this passage, we summarized the influence of the Warburg effect on the metastatic ability of CRC and the role of Warburg effect in the microenvironment remodeling of colorectal cancer, mainly focusing our attention on glycolytic metabolism in immune cells. Further, we discuss the effect of ...
Unlike cells with p53 mutation, those with intact p53 can manipulate cancer cells’ metabolism in response to chemotherapy, restraining the glycolytic pathway and decreasing the intracellular ATP levels, thereby boosting cells’ sensitivity to drugs. Fig. 7 The effect of p53 activation on cancer ...
Importantly, increased glycolytic metabolism from activated Ras does not stem from defective mitochondrial pathways. Even for Ras-mediated tumorigenesis, the importance of intact mitochondrial oxidative metabolism has been confirmed in vivo (Guo et al., 2011, Weinberg et al., 2010). Metabolic Enzymes ...