Trehalose phosphorylase activity in the vegetative mycelium was at a relatively high level until fruit-body initiation, suggesting the turnover of this disaccharide during the vegetative stage of the colony development. Trehalose phosphorylase activity in the stipes showed a peak level at the early ...
Glycogen phosphorylase inhibition improves beta cell function Glycogen phosphorylase (GP) is the key enzyme for glycogen degradation. GP inhibitors (GPi-s) are glucose lowering agents trapping glucose in the liver as ... L Nagy,J Márton,A Vida,... - 《British Journal of Pharmacology》 被引量...
Analogs of the 5′-phosphoryl group of pyridoxal-5′-phosphate were used to test the function of this position of the coenzyme in glycogen phosphorylase. Trans-5′-phosphonomethylene-5′-deoxypyridoxal and pyridoxal in the presence of noncovalently bound phosphate analogs produce active enzyme forms...
The process of breakdown of glycogen to glucose- 1 phosphate with help of certain enzymes is known as glycogenolysis. Through the action of the enzyme glycogen phosphorylase, one molecule of glucose will be removed from the non-reducing end of the compound, resulting in glucose-1 phosphate. The...
High resolution studies on the crystal structure of glycogen phosphorylase b have identified the catalytic site to which the substrate glucose-1-phosphate binds strongly with some local conformational changes. The site is situated 8 Å (phosphate-to-phosphate distance) from pyridoxal phosphate, an es...
(V); liver phosphorylase (VI, VIII, IX, X); and muscle phosphofructokinase (VII). Enzyme defects that can give rise to other carbohydrate diseases include galactokinase (A1); galactose 1-phosphate UDP transferase (A2); fructokinase (B); aldolase (C); fructose 1,6-diphosphatase deficiency (...
(redirected fromLiver glycogen phosphorylase) phos·phor·y·lase (fos-fōr'i-lās), An enzyme cleaving poly(1,4-α-d-glucosyl)nwith orthophosphate to form poly(1,4-α-d-glucosyl)n-1and α-d-glucose 1-phosphate. The active form of the enzyme is a phosphorylated protein. ...
GLYCOGEN phosphorylaseMUSCLE metabolismGLYCOGENSUPEROXIDE dismutaseSKELETAL muscleMitochondria and glycogen are co-distributed in skeletal muscles to regulate the metabolic status. Mitochondria are also redox centers that regulate the muscle function during exercise. However, the pathophysiological re...
Twenty-four asiatic acid derivatives have been synthesized and biologically evaluated as inhibitors of glycogen phosphorylase (GP). Within this series of compounds, asiatic acid benzyl ester (23; IC(50)=3.8 microM) exhibited more potent activity than its parent compound 1 (IC(50)=17 microM). SA...
The amount of energy that can be produced anaerobically is a function of the amount ofglycogenpresent—in all vertebrates about 0.5 percent of their muscles´ wet weight. 能以无氧方式产生的能量是存在的糖原量的功能——在所有脊椎动物中,糖原量约占其肌肉湿重的0.5%。