1981. Phosphorylation and dephosphorylation of glycogen phosphorylase: a prototype for reversible covalent enzyme modification. Curr. Top. Cell. Reg. 18:401-419.Krebs, E. G. (1981): Phosphorylation and dephosphorylation of glycogen phospho rylase: A prototype for reversible covalent enzyme modification...
Intracellular Distribution of Glycogen Synthase: Another Regulatory Mechanism of Glycogen Metabolism? Thus, covalent regulation by phosphorylation was originally described as the mechanism of activation of glycogen phosphorylase. Phosphorylase kinase was the ... JC Ferrer,S Baque,JM Fernandez-Novel,... -...
Structural studies of muscle glycogen phosphorylase during the last two decades have provided a detailed mechanism for the molecular basis of the control by phosphorylation and by allosteric effectors and the catalytic mechanism. Control by phosphorylation is effected by a disorder to order transition of...
(Chemistry) the chemical or enzymic introduction into a compound of a phosphoryl group (a trivalent radical of phosphorus and oxygen) Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014...
Glycogen synthase is a substrate for five distinct protein kinases in skeletal muscle which phosphorylate seven different serine residues on the enzyme. Cyclic-AMP-dependent protein kinase phosphorylates sites 1a, 1b and 2, phosphorylase kinase, site 2, glycogen synthase kinase 3, sites 3a, 3b and...
The two examples of phospho and dephospho proteins for which structural data were previously available (glycogen phosphorylase and isocitrate dehydrogenase) demonstrated two different mechanisms for control. In glycogen phosphorylase, activation by phosphorylation results in long-range allosteric changes. In ...
The slime mold Dictyostelium discoideum has two forms of the enzyme glycogen phosphorylase. The inactive phosphorylase 'b' form requires 5′ AMP for activity and is present in early development. The active phosphorylase 'a' form is 5′ AMP independent and occurs during later development. We here...
Kosolapoff,M Gennady - 《Journal of the American Chemical Society》 被引量: 188发表: 1948年 GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF This invention relates to a novel compound which is a glycogen phosphorylase inhibitor and its use in the treatment of diabetes ...
The effects of phosphorylation can be divided into three basic categories based on their speed of action: immediate, rapid, and slow (Fig.1). Immediate effects result from phosphorylations that induce an instantaneous biological effect, such as glycogen phosphorylase, which upon phosphorylation becomes...
Phosphorylation determines the activity of glycogen Phosphorylase A change in thinking about the purpose of phospho-proteins came about when it was shown, by Krebs and Fischer in 1956, that the difference in basal activity of purifiedglycogen phosphorylase, named phosphorylasebin its low-active state ...