1976. Structure of glycogen phosphorylase at 3.0-Å-resolution and its ligand binding sites at 6-Å. J. Biol. Chem. 251 : 6142–6146.Fletterick RJ, Sygusch J, Semple M, Madsen NB 1976 b) The structure of glycogen phosphorylase a at 3.0 A resolution and its ligand binding sites at...
1976 . Low-resolution structure of the glycogen phosphorylase a monomer and comparison with phosphorylase b . J Mol Biol 103 : 1 – 13 .Fletterick RJ, Sygusch J, Murray N, Madsen NB, Johnson LN. 1976. Low- resolution structure of the glycogen phosphorylase a monomer and compar- ison ...
Glycogen is a large polymer build-up by linear chains of α−1,4-linked glucose residues carrying α-1,6-linked branches. In the cytosol the energy storage particle is degraded by the concomitant action of glycogen phosphorylase and a debranching enzyme. Within the lysosome, no debranching enz...
Edmond H. FischerMichael M. ApplemanEdwin G. KrebsW. J. WhelanMargaret P. CameronJohn Wiley & Sons, LtdFischer EH, Appleman MM, Krebs EG. 1964. The structure of phosphorylases. In Ciba Foundation Symposium - Control of Glycogen Metabolism, ed. H Whelan, MP Cameron, pp. 94-106. ...
Glycogen phosphorylase (GP, EC 2.4.1.1) catalyze the rate-limiting step in glycogenolysis in animals, formingglucose-1-phosphate from the terminal alpha-1,4-glycosidic bond. Therefore, GP plays a crucial role in carbo-hydrate metabolism. In the present study, the full-length cDNA sequence of ...
Which one of the following is NOT a polysaccharide? A) Chitin B) Glycogen C) Cellulose D) Lipid How are glycogen phosphorylase and glycogen synthase reciprocally controlled? What are the circumstances under which glycogen would be broken down into its component glucose molecules? What is the name...
The end result is the activation of glycogen phosphorylase, an enzyme that breaks down glycogen into its glucose units, and the release of glucose into the bloodstream. The neurotransmitter action of epinephrine is terminated by reuptake into the neuron that released it, or breakdown to inactive ...
(Table S3). The predicted interaction partners of HP P44641 are elongation factor P, lysyl-tRNA synthetase, diaminopimelate decarboxylase, opacity-associated protein, glycogen phosphorylase, biotin synthase, lysyl-tRNA synthetase, acetate CoA-transferase beta subunit, opacity-associated protein OapB and ...
Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection. Several inhibitors of the large regulatory enzyme glycogen phosphorylase (GP) have been studied in crystallographic and kinetic experiments. GP catalyse...
PhK is one of the largest of the protein kinases and is composed of four types of subunit, with stoichiometry (αβγδ)4 and a total MW of 1.3 × 106. PhK catalyzes the phosphorylation of inactive glycogen phosphorylase b (GPb), resulting in the formation of active glycogen phosphorylase ...