We have previously shown that glutamine synthetase protein and mRNA are concentrated in the crypt region of the rat small intestine and that the activity of this enzyme is highest around the time of weaning. This anatomical location and time of peak activity are sites and periods of active ...
Define Glutamine synthetase. Glutamine synthetase synonyms, Glutamine synthetase pronunciation, Glutamine synthetase translation, English dictionary definition of Glutamine synthetase. n. A nonessential amino acid, C5H10N2O3, occurring widely in plant an
必应词典为您提供glutamine-synthetase的释义,un. 谷氨酰胺合成酶; 网络释义: 麸醯胺酸合成酵素;谷氨酰胺合酶;谷氨酸合成酵素;
Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows negligible glutamine-synthesizing activity in these cells at physiological glutamine levels. Here we show in mice that genetic ...
Glutamine synthetase (GS; EC 6.3.1.2), a key enzyme ofglutamate metabolism, and another enzyme possessing highhydroxylamine-L-glutamine transferase activity comparable to that of GS andtermed GS-like protein (GSLP) were purified from human brain concurrently. Intwo-dimensional electrophoresis, GS sub...
The change in glutamine synthetase activity has been studied under two conditions of liver growth, namely, mitotic growth after partial hepatectomy and nonmitotic growth during repletion after a fast. The surgical operation caused the enzyme activity in the liver to diminish to one half its normal ...
Cited in 32 publications. Glutamine Synthetase antibody for WB, IHC, IF-P, FC (Intra), ELISA and reacts with human, mouse, rat.
cells were able to adapt to glutamine deprivation and restore proliferation following an initial period of reduced growth. We show that expression of glutamine synthetase (GS), the enzyme responsible for de novo glutamine synthesis, increased during glutamine deprivation, and that pharmacological or sh...
Cited in 8 publications. Glutamine Synthetase antibody for WB, IHC, IF, ELISA and reacts with human, pig, zebrafish.
Here, we report that glutamine synthetase (GS) promotes cell proliferation by licensing mitotic progression independently of its metabolic function. GS depletion, but not impairment of its enzymatic activity, results in mitotic arrest and multinucleation across multiple lung and liver cancer cell lines,...