Glucose-6-phosphatase activity was estimated in various sheep tissues. It was appreciable in liver and kidney, detectable in intestine and salivary gland, but negligible in brain, muscle, stomach, rumen epithelium and mammary gland. The results suggest the relative importance of these tissues in con...
It occurs mainly in glycogenic tissues, such as the liver, where it plays an important role in the synthesis of glucose, a carbohydrate essential for tissue functioning. The effect of age on liver glucose-6-phosphatase activity was evaluated in male Wistar rats treated with mixed function ...
Glucose-6-phosphatase catalyzes the final reactions in both gluconeogenesis and glycolysis. It occurs mainly in glycogenic tissues, such as the liver, where it plays an important role in the synthesis of glucose, a carbohydrate essential for tissue functioning. The effect of age on liver glucose-...
phosphatase to glucose in the liver tissue. The activity of GLUT2 is not regulated by insulin, but hepatic glucokinase and glucose-6-phosphatase in the liver tissue are strongly regulated by insulin. Therefore, hepatic glucokinase is the first and rate-limiting step in glucose uptake and storage...
Glucose-6-phosphatase deficiency (G6P deficiency), or glycogen storage disease type I (GSDI), is a group of inherited metabolic diseases, including types Ia and Ib, characterized by poor tolerance to fasting, growth retardation and hepatomegaly resulting
(reversibly) toglucose-6-phosphateby the enzyme phosphoglucomutase. Those tissues also house the enzyme glucose-6-phosphatase, whichconvertsglucose-6-phosphate into free glucose that is secreted into the blood, thereby restoring blood glucose levels to normal. Glucose-6-phosphate is also taken up ...
Glucose-6-phosphatase deficiency (G6P deficiency), or glycogen storage disease type I (GSDI), is a group of inherited metabolic diseases, including types Ia and Ib, characterized by poor tolerance to fasting, growth retardation and hepatomegaly resulting
Importantly, lysosomal AMPK activation occurs in vivo in various physiological conditions such as starvation and calorie restric- tion14,17. Once cellular energy levels are low, the increased AMP causes allosteric changes in AMPK, which enables it to form a complex with LKB1-bound AXIN in the ...
[2,6]. As is portrayed inFig. 2.2, in the postabsorptive state, ~50% of endogenous glucose production derives from glycogenolysis and the remainder from gluconeogenesis, with the liver accounting for 80% of total glucose influx[1,7,8]. Moreover, the disposal of glucose occurs primarily ...
In the developing endosperms of wheat, maize, barley, and rice, the cytosolic isoform accounts for 65–95% of the total AGPase activity. Consequently, most of the storage starch biosynthesis in these tissues occurs through import of ADP-glucose into amyloplasts via a specialized ...