Structure-function relationshipThere are three members of the glucose-6-phosphatase (G6Pase) family: (1) the liver/kidney/intestine G6Pase-alpha (encoded by G6PC), which is a key enzyme in glucose homeostasis; (2) the ubiquitous G6Pase-beta (encoded by G6PC3); and (3) the islet-...
Regulation of rat liver glucose-6-phosphatase gene expression in different nutritional and hormonal states: gene structure and 5'-flanking sequence. The level of the catalytic subunit of liver (-6-Pase) was regulated by hormones commensurate with activity changes in vivo. exerts a dominant negative...
5-AMP, glycogenolysis would be enhanced while the islet glucose-6-phosphatase is still relatively inhibited by virtue of the high glucose concentration. Inhibition of the phosphatase would be particularly prominent if at the same time the
Glucose-6-Phosphatase Structure, Regulation, and Function: An Update Work on the glucose-6-phosphatase system has intensified and diversified extensively in the past 3 years. The gene for the catalytic unit of the liver enzy... JD Foster,BA Pederson,RC Nordlie - 《Experimental Biology & Medici...
Glucose-6-phosphatase deficiency (G6P deficiency), or glycogen storage disease type I (GSDI), is a group of inherited metabolic diseases, including types Ia and Ib, characterized by poor tolerance to fasting, growth retardation and hepatomegaly resulting from accumulation of glycogen and fat in ...
Thielavins as glucose-6- phosphatase (G6Pase) inhibitors: Producing strain, fermentation, isolation, structure elucidation and biological activities. J Antibiot 55: 941-951 (2002)Sakemi, S.; Hirai, H.; Ichiba, T.; Inagaki, T.; Kato, Y.; Kojima, N.; Nishida, H.; Parker, J.C.; ...
Glucose-6-phosphatase was localized within the rough endoplasmic reticulum of Sertoli, Leydig, and primitive spermatogonial cells as well as the nuclear ... SS Barham,JD Berlin - 《Cell & Tissue Research》 被引量: 38发表: 1974年 Fine structure and cytochemistry of testicular cells in men treate...
Glucose-6-phosphatase deficiency (G6P deficiency), or glycogen storage disease type I (GSDI), is a group of inherited metabolic diseases, including types Ia and Ib, characterized by poor tolerance to fasting, growth retardation and hepatomegaly resulting
A study of the serum glucose-6-phosphatase activity is carried out on 29 patients using the technique described by Koide and Oda. Using two substrates (G-6-P and PP) at different pH, the absence of glucose-6-phosphatase activity in the s... M Foz - 《Clinica Chimica Acta》 被引量:...
Because glycogen structure is normal in glucose-6-phos- phatase deficiency,about 10- 12molecules of glucose would have to be cycled to release 1 molecule of glucose (31). To account for glucose production of 0.2 pmollg liverlmin in glucose-6- phosphatase-deficient patients during fasting (3...