Carol Minassian, Sandrine Tarpin, Gilles Mithieux. (1998) Role of Glucose-6 Phosphatase, Glucokinase, and Glucose-6 Phosphate in Liver Insulin Resistance and Its Correction by Metformin. Biochemical Pharmacology 55 , 1213-1219 /Minassian C, Tarpin S, Mithieux G (1998) Role of glucose-6 ...
Glucose-6-phosphataseGlycogenMetabolite repair enzymeThe isoform of glucose-6-phosphatase in liver, G6PC1, has a major role in whole-body glucose homeostasis, whereas G6PC3 is widely distributed among organs but has poorly-understood functions. A recent, elegant analysis of neutrophil dysfunction ...
We investigated the role of glucose-6 phosphatase (Glc6Pase), glucokinase (GK), and glucose-6 phosphate (Glc6P) in liver insulin resistance, an early characteristic of type 2 diabetes, and its correction by metformin. We determined hepatic glucose production (HGP) by tracer dilution, and enzym...
Glucose-6-phosphate-dehydrogenase (G6PD), the rate-limiting enzyme of the Pentose Phosphate Pathway (PPP), is often activated in human malignancies to generate precursors for nucleotide and lipid synthesis. Here, we determined the clinical significance of G6PD in primary human HCC by analyzing RNA-...
glucose-6-phosphatase (G6P), fructose-1,6-biphosphatase (F16BP) and phosphoenolpyruvate carboxykinase (PEPCK) (Figure1)[12,14]. Akt activates mammalian target of rapamycin (mTOR) which promotes protein synthesis through activation of p70 ribosomal S6 kinase (p70S6K), and the inhibition of eIF4E...
Acs irreversibly transforms acetate to acetyl-CoA, consuming ATP [6]. This is a high affinity pathway with a low Km for acetate (200 μM) and low Vm, and therefore suitable for metabolizing low concentrations of acetate [5]. When growing on glucose, it is expressed during the stationary ...
ex Wight & Arn (Myrtaceae), which has been traditionally used in the treatment of diabetes by the tribes of The Nilgiris, Tamil Nadu, India. In this study, reverse pharmacophore mapping approach and text-based database search identified the dipeptidyl peptidase-IV, protein-tyrosine phosphatase 1...
Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce heart failure events by direct action on the failing heart that is independent of changes in renal tubular function. In the failing heart, nutrient transport into cardiomyocytes is increased, but nutrient utilization is impaired, leading to def...
Cells were grown at 30 °C in Hartwell’s complete (HC) medium with 2% glucose and lacking leucine and uracil (-Leu-Ura) to ensure retention of both plasmids to an OD600 of ∼3.0. Cells were harvested by centrifugation at 1000×g for 3 min at room temperature and resuspended in 2 ...
Acid phosphatase purified from maize scutellum, upon acylation with succinic anhydride, still shows negative co-operativity for the hydrolysis of glucose-6... MS Palma,AM Teno,A Rossi - 《Phytochemistry》 被引量: 7发表: 1983年 Escherichia coli H(+)-ATPase (ATP synthase): catalytic site and...