The activities of hepatic and renal glucose-6-phosphatase(s) were changed in a similar fashion to changes in hepatic and renal gluconeogenesis, respectively.doi:10.1080/00021369.1972.10860302SUZUKI, HirooFUWA, HidetsuguTaylor & FrancisJournal of the Agricultural Chemical Society of Japan...
Glucose-6-phosphataseGlycogenMetabolite repair enzymeThe isoform of glucose-6-phosphatase in liver, G6PC1, has a major role in whole-body glucose homeostasis, whereas G6PC3 is widely distributed among organs but has poorly-understood functions. A recent, elegant analysis of neutrophil dysfunction ...
We investigated the role of glucose-6 phosphatase (Glc6Pase), glucokinase (GK), and glucose-6 phosphate (Glc6P) in liver insulin resistance, an early characteristic of type 2 diabetes, and its correction by metformin. We determined hepatic glucose production (HGP) by tracer dilution, and enzym...
Gluconeogenesis from pyruvate and glycerol by liver slices were both increased significantly in rats fed the high fat diet, while feeding the high protein diet caused increase of renal gluconeogenesis from pyruvate and glycerol. The activities of hepatic and renal glucose-6-phosphatase(s) were ...
Glucose-6-phosphate-dehydrogenase (G6PD), the rate-limiting enzyme of the Pentose Phosphate Pathway (PPP), is often activated in human malignancies to generate precursors for nucleotide and lipid synthesis. Here, we determined the clinical significance of G6PD in primary human HCC by analyzing RNA-...
Acs irreversibly transforms acetate to acetyl-CoA, consuming ATP [6]. This is a high affinity pathway with a low Km for acetate (200 μM) and low Vm, and therefore suitable for metabolizing low concentrations of acetate [5]. When growing on glucose, it is expressed during the stationary ...
FoxO6 induce the expression of two key enzymes in gluconeogenesis, glucose-6-phosphatase (G6Pase) and phosphoenolpyruvates carboxykinase (PEPCK) [30,31,32,33,34]. Consistently, knockout of eitherFoxo1alone orFoxo1/3/4altogether specifically in mouse liver leads to lower blood glucose levels ...
The 1 H NMR spectrum obtained with the 伪- and 尾-anomers of d -[1- 2 H]fructose 6-phosphate generated from d -glucose 6-phosphate sequentially exposed in ... R Willem,F Malaisse Lagae,W Malaisse - 《Biochimie》 被引量: 98发表: 1991年 Anomeric Equilibria in Derivatives of Amino Sug...
ex Wight & Arn (Myrtaceae), which has been traditionally used in the treatment of diabetes by the tribes of The Nilgiris, Tamil Nadu, India. In this study, reverse pharmacophore mapping approach and text-based database search identified the dipeptidyl peptidase-IV, protein-tyrosine phosphatase 1...
glucose-6-phosphatase (G6P), fructose-1,6-biphosphatase (F16BP) and phosphoenolpyruvate carboxykinase (PEPCK) (Figure1)[12,14]. Akt activates mammalian target of rapamycin (mTOR) which promotes protein synthesis through activation of p70 ribosomal S6 kinase (p70S6K), and the inhibition of eIF4E...