General Features of the G6PC Family In mammals, the highest levels of glucose-6-phosphatase activity are found in liver; however, progress in studying the enzyme responsible for this activity was impeded for many years because of its location in the ER2 membrane and its inherent instability (...
While occupying a strategic, crossroad metabolic position, glucose-6-phosphatase is unique among enzymes involved in carbohydrate metabolism with respect to its intracellular location. The presence of this enzyme as a part of the membrane of the endoplasmic reticulum, as well as its hydrolytic ...
The glucose-6-phosphatase and Na-K-ATPase activities in the nuclear membrane fraction were very low. In the gel electrophoresis, in addition to many ... Franke,W W. - 《Journal of Cell Biology》 被引量: 230发表: 1970年 Identification of tyrosine-phosphorylated proteins associated with the nu...
THE enzyme glucose-6-phosphatase cannot be classified as either acid phosphatase or alkaline phosphatase. It is highly specific and is differentiated from non-specific acid and alkaline phosphatases on the basis of location and behaviour. So far, no systematic study has been made regarding the ...
The intensity of HCC relative to the normal liver (as in other tissues) in FDG-PET depends on the ratio between the phosphorylation of FDG and the dephosphorylation of FDG-6P by glucose-6-phosphatase72. Because glucose-6-phosphatase expression is variable in HCC, FDG-PET imaging only has ...
Sugar-induced redox activation of AGPase is lost in transgenic plants expressing a trehalose 6-phosphate phosphatase (EC 3.1.3.12), which causes a reduction in trehalose 6-phosphate levels [134]. However, no significant fluctuations in trehalose 6-phosphate levels have been observed ...
the cells are generally characterized by enhanced glucose metabolism partially due to (1) an increase in the activity of glucose transporters, (2) an increased rate of phosphorylation activity, (3) a reduction of phosphatase activity or, (4) a dynamic alteration in the balance among all thesepr...
In the liver, AMPK helps regulate glucose homeostasis by reducing the gluconeogenic key genes including phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase)[9, 10]. Further- npg 1062 www.nature.com/aps Zhou R et al more, the AMPK activator AICAR[11] could enhance the ...
A novel and essen- Cell Research | Vol 22 No 6 | June 2012 tial mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo. Genes Dev 2003; 17:2138- 2150. 24 Van Hoof C, Martens E, Longin S, et al. Specific interactions of PP2A and PP2A-like ...
Fludeoxyglucose F 18 is transported through the cell membrane by facilitative glucose transporter proteins and is phosphorylated within the cell to [18F] FDG-6- phosphate by the enzyme hexokinase. Once phosphorylated it cannot exit until it is dephosphorylated by glucose-6-phosphatase. Therefore, ...