李瑞芳等证明了非诺贝特激活PPAR-α后可以通过调控转录因子NFATc4来抑制ET-1诱导的心肌肥大反应[3]。胰高血糖素样肽-1 (GLP-1) 是一种是由肠道内L细胞分泌的一种十分重要的肠促胰岛素, 其受体激动剂Exendin-4是由动物唾液分泌的GLP-1类似物[4,5]。近年来对GLP-1的研究发现其对心血管系统具有保护作用, 如...
In a 3xTg-AD mouse model, exenatide treatment reversed high fat diet-induced impairments of BDNF signaling and reduced levels of NF-κB and peroxisome proliferator-activated receptor proteins (PPARs) α and γ, indicating reduced inflammation; however, there was no significant effect on systemic ...
本公开文本总体上涉及GLP‑1激动剂和包含所述GLP‑1激动剂的药物组合物,以及用于治疗GLP‑1相关疾病、障碍或病症的方法。 法律状态 序号法律状态公告日法律状态法律状态信息 1 2023-02-08 公布 公布 权利要求 1.一种式I的化合物: 或其药学上可接受的盐或溶剂化物,其中: X 1 、X 2 和X 5 独立地...
The KEGG analyses revealed that insulin-signaling-related PI3K-AKT pathway, PPAR signaling, and several lipid-metabolism-related pathways, including GL metabolism and cholesterol metabolism (Figure 7B), are among the top enriched pathways in the SAT. We then analyzed the genes that were significantly...
Given that the likely dominant mode of action of gut hormone agonists is upstream on weight, initial combinations might focus on agents which have been shown to have a more direct effect on fibrosis, which would include FGF21 (fibroblast growth factor 21) agonists and the pan-PPAR (peroxisome...
Exenatide Activates the APPL1-AMPK-PPARα Axis to Prevent Diabetic Cardiomyocyte Apoptosis. J. Diabetes Res. 2016, 2016, 4219735. [Google Scholar] [CrossRef] Hu, S.Y.; Zhang, Y.; Zhu, P.J.; Zhou, H.; Chen, Y.D. Liraglutide directly protects cardiomyocytes against reperfusion injury ...
International Journal of Environmental Research and Public Health Article Resistance Exercise Training Attenuates the Loss of Endogenous GLP-1 Receptor in the Hypothalamus of Type 2 Diabetic Rats Se Hwan Park 1, Jin Hwan Yoon 1, Dae Yun Seo 2 , Tae Nyun Kim 2, Jeong Rim Ko 2 and Jin Han ...
Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. Biochimie. 86: 743-761.Yu S,Viswakarma N,Batra S K,Sambasiva Rao M,Reddy J K.Identification of promethin and PGLP as two novel up-regulated genes in PPARγ1-induced ...
In this context, given the involvement of PPAR-gamma and adiponectin in the improvement of insulin resistance [121], it is possible to hypothesize that the upregulation of adiponectin expression observed after treatment with GLP-1 administration, especially liraglutide [100,122], and exenatide [123...
TZD, also known as pioglitazone, is a synthetic peroxisome proliferator-activated receptor γ (PPARγ) stimulator, and it is a potent insulin sensitizer with multiple mechanisms of action. These drugs increase glucose consumption in muscle tissues, reduce the levels of glycerol, free fatty acids ...