Dual agonists activating the peroxisome proliferator-activated receptors alpha and gamma (PPAR蓱/) have beneficial effects on glucose and lipid metabolism in patients with type 2 diabetes, but their development was discontinued due to potential adverse effects. Here we report the design and preclinical...
李瑞芳等证明了非诺贝特激活PPAR-α后可以通过调控转录因子NFATc4来抑制ET-1诱导的心肌肥大反应[3]。胰高血糖素样肽-1 (GLP-1) 是一种是由肠道内L细胞分泌的一种十分重要的肠促胰岛素, 其受体激动剂Exendin-4是由动物唾液分泌的GLP-1类似物[4,5]。近年来对GLP-1的研究发现其对心血管系统具有保护作用, 如...
406、在另一实施方案中,本发明的化合物与下列的一种或多种组合施用:治疗nash的药剂(包括,但不限于:pf-05221304),fxr激动剂(例如,奥贝胆酸),pparα/δ激动剂(例如,elafibranor),合成的脂肪酸-胆酸缀合物(例如,aramchol),半胱天冬酶抑制剂(例如,恩利卡生(emricasan)),抗赖氨酰氧化酶同系物2(loxl2)单克隆抗体...
本公开文本总体上涉及GLP‑1激动剂和包含所述GLP‑1激动剂的药物组合物,以及用于治疗GLP‑1相关疾病、障碍或病症的方法。 法律状态 序号法律状态公告日法律状态法律状态信息 1 2025-01-21 公布 公布 权利要求 1.一种式I的化合物: 或其药学上可接受的盐或溶剂化物,其中: X 1 、X 2 和X 5 独立地...
The KEGG analyses revealed that insulin-signaling-related PI3K-AKT pathway, PPAR signaling, and several lipid-metabolism-related pathways, including GL metabolism and cholesterol metabolism (Figure 7B), are among the top enriched pathways in the SAT. We then analyzed the genes that were significantly...
In a 3xTg-AD mouse model, exenatide treatment reversed high fat diet-induced impairments of BDNF signaling and reduced levels of NF-κB and peroxisome proliferator-activated receptor proteins (PPARs) α and γ, indicating reduced inflammation; however, there was no significant effect on systemic ...
P124The ppargamma agonist pioglitazone reverses pulmonary arterial hypertension (PAH) and prevents right heart failure through fatty acid oxidation (fao) Purpose: So far, no intervention could fully reverse PAH or even prevent pressure overload heart failure, in the well-established SuHx rat model ...
Fenofibrate is a peroxisome proliferator-activated receptor (PPAR)-伪 agonist that showed beneficial effects on total cardiovascular risk in patients with type 2 diabetes in the Fenofibrate Intervention and Event Lowering in Diabetes (FI... KL Ong,Kerry-Anne Rye,R O'Connell,... - 《Journal of ...
Given that the likely dominant mode of action of gut hormone agonists is upstream on weight, initial combinations might focus on agents which have been shown to have a more direct effect on fibrosis, which would include FGF21 (fibroblast growth factor 21) agonists and the pan-PPAR (peroxisome...
Müller 1,2 ✉ Dual agonists activating the peroxisome proliferator-activated receptors alpha and gamma (PPARɑ/ɣ) have beneficial effects on glucose and lipid metabolism in patients with type 2 diabetes, but their development was discontinued due to poten- tial adverse effects. Here ...