GLP-1R激动剂的心脏保护作用依赖于经典的GLP-1R,伴随着心脏保护基因(包括Akt、GSK3β、PPARΔ、NRF-2和HO-1)在心脏的表达增强[12],并似乎部分独立于GLP-1引起的体重减轻。用利拉鲁肽治疗原代新生小鼠心肌细胞可以增加cAMP的生成并...
GLP-1对心脏损伤后心功能的影响 内皮功能障碍是与胰岛素抵抗和T2DM相关的常见并发症。用GLP-1治疗2型糖尿病合并冠脉疾病的患者可改善内皮功能,而不影响胰岛素抵抗[8]。在GLP-1治疗1型糖尿病的研究中也有类似的发现[19],但GLP-1对内...
本实验重点通过观察糖尿病病心肌病大鼠治疗前后心脏组织的胶原含量的变化以及PPAR-α、ET-1的蛋白表达水平, 来探讨GLP-1类似物治疗糖尿病心肌病的可能作用机制。 糖尿病心肌病 (DCM) 是一种特异性心肌病, 病理表现为心肌肥厚和心肌纤维化, 是糖尿病患者的主要心脏并发症之一[1,2]。近年来研究发现, 心肌纤维化...
Dual-agonists activating the peroxisome proliferator-activated receptors alpha and gamma (PPAR/) have shown beneficial effects on glucose and lipid metabolism in patients with type 2 diabetes, but their development was discontinued due to unfavorable cardiovascular and/or renal effects. Here we report ...
Müller 1,2 ✉ Dual agonists activating the peroxisome proliferator-activated receptors alpha and gamma (PPARɑ/ɣ) have beneficial effects on glucose and lipid metabolism in patients with type 2 diabetes, but their development was discontinued due to poten- tial adverse effects. Here ...
说明 PPAR[3/8 在葡 萄糖刺激 L 细胞分泌 GLP一1 中起一定作用。 2 蛋 白质 刺激 L 细胞 分泌 GLP-1 的 机制 蛋 白质是刺激 L 细胞分 泌 GLP.1 中相对较 弱 的营养物质。肉类 的水解产物可呈剂量依赖性地刺 激 NCI.H716 、GLUTag 和 STC一1 细 胞分 泌 GLP一1¨ 。 这一作用可被 电压 ...
GLP-1 had no effect on the PPAR-α protein, but it significantly increased the expression of ABCA1 protein. In groups treated with GLP-1, miR-19b levels were considerably reduced. The purpose of establishing miR-19b inhibition and overexpression was to investigate the impact of a miR-19b ...
Abbreviations| IL-6; interleukin-6, TNF-α: tumor necrosis factor-alpha, CRP: C-reactive protein, NDC: non-diabetic control, DC: diabetic control, MET: metformin. 3.4. Effect of treatment on lipidemia We also estimated the therapeutic effects of genistein on lipid profile biomarkers by ...
(ADP-ribose) polymerase 1; PINK1: the mitochondrial kinase; PI3K: phosphoinositide 3-kinase; PKA: protein kinase A; PPAR: peroxisome proliferator-activated receptor; P10: cleaved caspase 1; P4HA1: prolyl 4-hydroxylase subunit alpha-1; p70S6K: p70 ribosomal protein S6 kinase; Rac1: Ras-...
PPARalpha-mediated upregulation of uncoupling protein-2 switches cyanide-induced apoptosis to necrosis in primary cortical cells. Peroxisome proliferator-activated receptor alpha (PPARalpha) is a member of the nuclear factor PPAR family that regulates a variety of cellular functions, ... L Li,K Prab...