本实验重点通过观察糖尿病病心肌病大鼠治疗前后心脏组织的胶原含量的变化以及PPAR-α、ET-1的蛋白表达水平, 来探讨GLP-1类似物治疗糖尿病心肌病的可能作用机制。 糖尿病心肌病 (DCM) 是一种特异性心肌病, 病理表现为心肌肥厚和心肌纤维化, 是糖尿病患者的主要心脏并发症之一[1,2]。近年来研究发现, 心肌纤维化...
GLP-1R激动剂的心脏保护作用依赖于经典的GLP-1R,伴随着心脏保护基因(包括Akt、GSK3β、PPARΔ、NRF-2和HO-1)在心脏的表达增强[12],并似乎部分独立于GLP-1引起的体重减轻。用利拉鲁肽治疗原代新生小鼠心肌细胞可以增加cAMP的生成并减...
GLP-1R激动剂的心脏保护作用依赖于经典的GLP-1R,伴随着心脏保护基因(包括Akt、GSK3β、PPARΔ、NRF-2和HO-1)在心脏的表达增强[12],并似乎部分独立于GLP-1引起的体重减轻。用利拉鲁肽治疗原代新生小鼠心肌细胞可以增加cAMP的生成并减少细胞凋亡[12]。GLP-1R激动剂在啮齿类动物心脏具有直接的细胞自主抗凋亡作用,GL...
Dual agonists activating the peroxisome proliferator-activated receptors alpha and gamma (PPAR蓱/) have beneficial effects on glucose and lipid metabolism in patients with type 2 diabetes, but their development was discontinued due to potential adverse effects. Here we report the design and preclinical...
GLP-1R激动剂的心脏保护作用依赖于经典的GLP-1R,伴随着心脏保护基因(包括Akt、GSK3β、PPARΔ、NRF-2和HO-1)在心脏的表达增强[12],并似乎部分独立于GLP -1引起的体重减轻。用利拉鲁肽治疗原代新生小鼠心肌细胞可以增加cAMP的生成并减少细胞凋亡[12]。GLP-1R激动剂在啮齿类动物心脏具有直接的细胞自主抗凋亡作用,...
,onceweekly;PPAR-αγ,peroxisomeproliferator‐activatedrecepto rs-αandγ;SGLT-1i,sodium–glucoseco-transporter-1inhibitor;S GLT-2i,sodium–glucoseco-transporter-2inhibitor;s.c.subcutane ously;SU,sulphonylurea;TZD,thiazolidinedione.1.HolmanRRet ...
Combination therapy using a dual PPAR-α/PPAR-γ activator and a GLP-1 derivative for the treatment of metabolic syndrome and related diseases and disorders The present invention relates to a pharmaceutical composition comprising a dual Peroxisome Proliferator-Activated Receptor-alpha/Peroxisome Proliferator...
In a 3xTg-AD mouse model, exenatide treatment reversed high fat diet-induced impairments of BDNF signaling and reduced levels of NF-κB and peroxisome proliferator-activated receptor proteins (PPARs) α and γ, indicating reduced inflammation; however, there was no significant effect on systemic ...
PPARalpha-mediated upregulation of uncoupling protein-2 switches cyanide-induced apoptosis to necrosis in primary cortical cells. Peroxisome proliferator-activated receptor alpha (PPARalpha) is a member of the nuclear factor PPAR family that regulates a variety of cellular functions, ... L Li,K Prab...
说明 PPAR[3/8 在葡 萄糖刺激 L 细胞分泌 GLP一1 中起一定作用。 2 蛋 白质 刺激 L 细胞 分泌 GLP-1 的 机制 蛋 白质是刺激 L 细胞分 泌 GLP.1 中相对较 弱 的营养物质。肉类 的水解产物可呈剂量依赖性地刺 激 NCI.H716 、GLUTag 和 STC一1 细 胞分 泌 GLP一1¨ 。 这一作用可被 电压 ...