22. Drucker, D. J., Philippe, J., Mojsov, S., Chick, W. L., and Habener, J. F. (1987) Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proceedings of the National Academy of Sciences of...
[2] Sarkar, S., Fekete, C., Legradi, G., Lechan, R.M. 2003. Glucagon like peptide-1 (7-36) amide (GLP-1) nerve terminals densely innervate corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Brain...
[15] Dumoulin, V., Moro, F., Barcelo, A., Dakka, T., Cuber, J.C. 1998. Peptide YY, glucagonlike peptide-1, and neurotensin responses to luminal factors in the isolated vascularly perfused rat ileum. Endocrinology 139:3780-3786. [16] Rocca, A.S., LaGreca, J., Kalitsky, J., ...
V. 2003. Peptides that regulate food intake: glucagon-like peptide 1-(7-36) amide acts at lateral and medial hypothalamic sites to suppress feeding in rats. Am J Physiol Regul Integr Comp Physiol 284:R1427-1435.
[9] Shousha, S., Nakahara, K., Nasu, T., Sakamoto, T., Murakami, N. 2007. Effect of glucagon-like peptide-1 and -2 on regulation of food intake, body temperature and locomotor activity in the Japanese quail. Neurosci Lett 415:102-107. ...
Glucagon like peptide-1 (GLP-1) is a 30 or 31 amino acid long peptide hormone mainly secreted by 3 tissues in the human body: enteroendocrine L cells in the distal intestine, alpha cells in the pancreas, and the central nervous system [1]. Through its interaction with the GLP-1 receptor...
[36] Holz, G.G., Leech, C.A., Heller, R.S., Castonguay, M., Habener, J.F. 1999. cAMPdependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-...
胰高血糖素样肽-1(glucagon -like peptide 1, GLP-1)是一种肠道激素,在调节血糖、以葡萄糖依赖的方式促进胰岛素分泌、抑制胃排空和摄食等方面发挥重要作用。近年来GLP-1类似物以及防止GLP-1降解的药物现已用于治疗T2DM,因此,深入探究GLP-1内源性释放机制以及对葡萄糖稳态的调控机制将有助于为T2DM的诊断和治疗...
July 26, 2024 Nabila El Akal Life Sciences and Healthcare The EU is facing a shortage of medicines that act on a hormone called Glucagon-Like Peptide-1 (GLP-1), which helps control blood sugar and appetite, which is affecting the EU Member States since 2022 and will continue throughout ...
近日,被誉为“诺奖风向标”的拉斯克奖将临床医学研究奖授予了发现和开发胰高糖素样肽-1(glucagon-like peptide-1,GLP-1)类药物的三位科学家——乔尔· 哈本纳(Joel Habener)、罗蒂·比耶尔·克努森(Lotte B…