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[2] Sarkar, S., Fekete, C., Legradi, G., Lechan, R.M. 2003. Glucagon like peptide-1 (7-36) amide (GLP-1) nerve terminals densely innervate corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Brain Res 985:163-168. [3] Ghosal, S., Packard, A.E.B....
4.Sara J. Brandt, Anna Götz, Matthias H. Tschöp, Timo D. Müller, Gut hormone polyagonists for the treatment of type 2 diabetes, Peptides 100 (2018) 190–201 5.340-OR: LY3437943 (LY) , a Novel Triple GIP/GLP-1/Glucagon Receptor Agoni...
近日,被誉为“诺奖风向标”的拉斯克奖将临床医学研究奖授予了发现和开发胰高糖素样肽-1(glucagon-like peptide-1,GLP-1)类药物的三位科学家——乔尔· 哈本纳(Joel Habener)、罗蒂·比耶尔·克努森(Lotte Bjerre Knudsen)、斯韦特兰娜·莫伊索夫(Svetlana Mojsov)。 GLP-1类药物的研发毫无疑问具有划时代的意义...
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胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)是一种由肠道 L 细胞分泌的激素,其受体(GLP-1R)广泛分布于包括中枢神经系统、心血管系统、肌肉、胃肠道在内的多个器官和组织。GLP-1 具有葡萄糖浓度依赖性降糖作用,其受体激动剂(GLP-1RA)能模拟 GLP-1 的生理作用,是治疗糖尿病与肥胖症的重要药物。此外,GL...
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