[9] Orskov, C., Holst, J.J., Knuhtsen, S., Baldissera, F.G., Poulsen, S.S., Nielsen, O.V. 1986. Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas. Endocrinology 119:1467-1475. [...
包括:艾伯维(AbbVie)的长效GLP-2R激动剂CLF065,正在开展针对炎症性肠病的1期临床;派金生物的重组酰化GLP-2类似物PJ020,已于今年在中国获批临床,拟用于治疗化疗相关性腹泻;Progen公司的GLP-1和GLP-2双靶点药物PG-102,正在开展治疗肥胖适应症...
[9] Orskov, C., Holst, J.J., Knuhtsen, S., Baldissera, F.G., Poulsen, S.S., Nielsen, O.V. 1986. Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted sepa...
[2]Wei, Y., Mojsov, S. 1995. Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett 358:219-224. [3]Wei, Y., Mojsov, S. 1996. Distribution of GLP-1 and PACAP receptors...
激素原转化酶可将胰高糖素原分子切成不同大小的肽段,包括含肠高血糖素相关胰多肽(GRPP; 氨基酸片段1 - 30)、胰高糖素(氨基酸片段33 - 61)、胃泌酸调节素(OXM;氨基酸片段 33 - 69)的肠高血糖素(氨基酸片段1 - 69)和含胰高糖素样肽1 (GLP-1;氨基酸片段 72-107/108)、胰高糖素样肽2 (GLP-2;氨基...
CAS号119637-73-9INCIGLP-1(7-36) 特性&功效 理化性质&指标 有效物含量98% 产品描述 Name:GLP-1(7-36), IRP peptide Cas No:119637-73-9, 107444-51-9 Formula: C149H226N40O45 Molecular: 3297 Sequence: HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR ...
[2] Wei, Y., Mojsov, S. 1995. Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett 358:219-224. [3] Wei, Y., Mojsov, S. 1996. Distribution of GLP-1 and PACAP recep...
3 3 CN 113292646 B 说明书 1/14 页 GLP‑1/胰高血糖素双重激动剂融合蛋白 技术领域 [0001] 本发明属于生物技术或生物医药领域,具体涉及一种GLP‑1(Glucagon‑like peptide,GLP‑1)/胰高血糖素双重激动剂融合蛋白。 背景技术 [0002] 肥胖症是指机体脂肪总含量过多和/或局部含量增多及分布异常,是由...
The fusion peptide comprises as component (I) N-terminally a GLP-1(7-35, 7-36 or 7-37) sequence and as component (II) C-terminally a peptide sequence of at least 9 amino acids or a functional fragment, variant or derivative thereof. Component (II) is preferably a full or partial ...
[0028] “胰高血糖素样肽‑1(Glucagon‑like peptide‑1,GLP‑1)”是小肠的L细胞响应于 饮食摄取而分泌的一种激素,其根据血糖浓度促进从胰脏的胰岛素分泌并抑制胰高血糖素 的分泌以协助降低血糖浓度的作用。 [0029] 根据最初报告,“葡萄糖依赖性胰岛素释放肽(Glucose‑dependent insulinotropic polypeptide或...