35. https://www.buffalo.edu/news/releases/2016/04/030.html 36. https://hms.harvard.edu/news/gut-hormone-insights 37.https://www.gov.uk/drug-safety-update/exenatide-byetta-risk-of-severe-pancreatitis-and-renal-failure 38.Video series: The Story of GLP-1 by Novo...
[2] Sarkar, S., Fekete, C., Legradi, G., Lechan, R.M. 2003. Glucagon like peptide-1 (7-36) amide (GLP-1) nerve terminals densely innervate corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Brain...
[2] Sarkar, S., Fekete, C., Legradi, G., Lechan, R.M. 2003. Glucagon like peptide-1 (7-36) amide (GLP-1) nerve terminals densely innervate corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Brain Res 985:163-168. [3] Ghosal, S., Packard, A.E.B....
在主要临床终点上，24周时，体重百分比方面，1 mg Retatrutide组为-7.2%，4 mg组为-12.9%，8mg组为-17.3%，而12 mg的组达到了-17.5%，安慰剂组为-1.6%。此外，次要临床终点48周的体重变化上，12mg组的体重降幅达到24.2%（安慰剂组为-2.1%），8mg两个亚组也都超过了20%。（图片来源：《Triple–H...
[52]Crajoinas, R.O., Oricchio, F.T., Pessoa, T.D., Pacheco, B.P., Lessa, L.M., Malnic, G., et al. 2011. Mechanisms mediating the diuretic and natriuretic actions of the incretin hormone glucagon-like peptide-1. Am J Physiol Renal Physiol 301:F355-363. ...
[52] Crajoinas, R.O., Oricchio, F.T., Pessoa, T.D., Pacheco, B.P., Lessa, L.M., Malnic, G., et al. 2011. Mechanisms mediating the diuretic and natriuretic actions of the incretin hormone glucagon-like peptide-1. Am J Physiol Renal Physiol 301:F355-363. ...
Retatrutide则为“三重调节”分子,能模仿三种不同的饥饿调节激素:GLP-1、GIP和GCG,因此被称为“Triple–Hormone-Receptor Agonist”。 图19.Retatrutide的分子结构 Lilly在诸多管线方面已经开始攻城拔寨,能够后来居上吗?只能把这个问题交给时光老人。 后记
[2]GROMADA J, HOLST J J, RORSMAN P. Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1 [J]. Pflügers Archiv, 1998, 435(5): 583-594. [3]蒋镜清, 符玲, 谈梦璐, 陈圣福.胰高血糖素样肽-1(GLP-1)类似物研究进展[J]. 高校化学工程学报. 2020,...
Nogueiras R, Nauck MA, Tschöp MH. Gut hormone co-agonists for the treatment of obesity: from bench to bedside. Nat Metab. 2023 Jun;5(6):933-944. doi: 10.1038/s42255-023-00812-zIF: 18.9 Q1 . Epub 2023 Jun 12. PMID: 37308724....
Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells. Endocrinology 130:2890-2896.[44] Wang Y, Egan JM, Raygada M, Nadiv O, Roth J, Montrose-Rafizadeh C,1995. Glucagon-like peptide-1 affects ...